ArticleTherapeutic advances in musculoskeletal disease2011
Atypical femur fractures: a review of the evidence and its implication to clinical practice.
Article in Therapeutic advances in musculoskeletal disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Epidemiology and Postoperative Outcomes of Atypical Femoral Fractures in Older Adults: A Systematic Review.The journal of nutrition, health & aging · 2017Pooled it
- Review
- Musculoskeletal mimics of lumbosacral radiculopathy.Muscle & nerve · 2025Review
- Recommendations on the post-acute management of the osteoporotic fracture - Patients with "very-high" Re-fracture risk.Journal of orthopaedic translation · 2022Article
- Review
- Secular Trends in the Pharmacologic Treatment of Osteoporosis and Malignancy-Related Bone Disease from 2009 to 2020.Journal of general internal medicine · 2022Article
- Asian Ethnicity and Femoral Geometry in Atypical Femur Fractures: Independent or Interdependent Risk Factors?JBMR plus · 2022Article
- A scorecard for osteoporosis in Canada and seven Canadian provinces.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Review
- A Mixed Methods Study Exploring Older Womens' Attitudes Toward Osteoporosis Medications: Adapting a Health Communication Framework.Women's health reports (New Rochelle, N.Y.) · 2020Article
- Article
- Article
- Unmet needs and current and future approaches for osteoporotic patients at high risk of hip fracture.Archives of osteoporosis · 2016Review
- Selective Estrogen Receptor Modulators.Asian spine journal · 2016Review
- Osteoporosis prevention, screening, and treatment: a review.Journal of women's health (2002) · 2014Review
- Atypical femoral fractures: retrospective radiological study of 319 femoral fractures and presentation of clinical cases.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
- Progression of bisphosphonate-associated impending atypical femoral fracture despite prophylactic cephalomedullary nailing: A case report and review of literature.Journal of clinical orthopaedics and traumaArticle
- Atypical Femoral Fractures: Implications for the Advanced Practitioner in Oncology.Journal of the advanced practitioner in oncologyReview
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whilst bisphosphonates are an established modality in the treatment of osteoporosis, there have been increasing concerns regarding the risk of an unusual form of femur fracture amongst patients receiving bisphosphonates for prolonged periods. These fractures, referred to as 'atypical', have been characterized by a number of clinical and radiographic features that distinguish them from 'typical' osteoporotic fractures. The evidence base is currently split between a large number of case series demonstrating an association between the occurrence of atypical fractures and bisphosphonate use and several population-based studies that do not confirm such an association. Hence, a degree of uncertainty surrounds this important issue. In this review, we examine the emerging evidence on atypical femur fractures, assess hypotheses on their biomechanical evolution and discuss the wider clinical implications of this phenomenon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.