Evidence map›Paper›PMID 22870479›Full record

ArticleTherapeutic advances in musculoskeletal disease2011

'Old drugs for new applications': can orthopedic research benefit from this strategy?

Xiaohua Pan, Wenxiang Cheng, Jiali Wang, Ling Qin, Yuxiao Lai, Jian Tang, Peng Shang, Peigen Ren, Peng Zhang

Abstract read
In one paragraph

Article in Therapeutic advances in musculoskeletal disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Selective killing effect of oxytetracycline, propafenone and metamizole on A549 or Hela cells.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaohua PanDepartment of Orthopaedics, Second Clinical Medical College, Ji'nan University, Shenzhen, Guangdong Province, China.
Wenxiang Cheng
Jiali Wang
Ling Qin
Yuxiao Lai
Jian Tang
Peng Shang
Peigen Ren
Peng Zhang

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New drug exploration is difficult in a clinical setting and the development of new drugs may be costly and time consuming. With further research into the pathological mechanisms and etiology of diseases as well as the rapid development of biological techniques, many 'old drugs' that have been applied in clinics may have new therapeutic functions which may shed light on clinical management. Based on this, we have investigated the 'old drugs for new applications' strategy in pharmacology which may be less expensive and more efficient in the clinical setting. In this paper we have explored and illustrated the potential applications of 'old drugs' for the treatment of orthopedic diseases, especially in arthritis and osteoporosis therapy.

Indexed as

cholinergic anti-inflammatory pathwaycholinergic antinociceptive pathwayold drugs for new applicationsorthopedic researchrheumatoid arthritis

Identifiers

PMID22870479
PMCPMC3382676

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.