ArticleTherapeutic advances in musculoskeletal disease2010
Can Hip Fracture Prediction in Women be Estimated beyond Bone Mineral Density Measurement Alone?
Article in Therapeutic advances in musculoskeletal disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Frailty and osteosarcopenia in older men: a hidden vulnerability.BMC geriatrics · 2026Article
- Association of frailty with fragility fractures and all‑cause mortality in adults: evidence from the National Health and Nutrition Examination Survey.BMC musculoskeletal disorders · 2026Article
- Burden of screening and treatment of bone health markers amongst elderly patients with proximal femur fractures.Journal of orthopaedic surgery and research · 2025Article
- Social vulnerability index enhances FRAX prediction of hip fractures in fall patients.Scientific reports · 2025Article
- Homeostatic Expansion of CD4+ T Cells Promotes Cortical and Trabecular Bone Loss, Whereas CD8+ T Cells Induce Trabecular Bone Loss Only.The Journal of infectious diseases · 2017Article
- A biomechanical sorting of clinical risk factors affecting osteoporotic hip fracture.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Review
- Assessing bone quality in terms of bone mineral density, buckling ratio and critical fracture load.Journal of bone metabolism · 2014Article
- Novel assessment tools for osteoporosis diagnosis and treatment.Current osteoporosis reports · 2014Review
- Pitfalls in the external validation of FRAX.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Review
- Determinants of fracture risk in a UK-population-based cohort of older women: a cross-sectional analysis of the Cohort for Skeletal Health in Bristol and Avon (COSHIBA).Age and ageing · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The etiology of hip fractures is multifactorial and includes bone and fall-related factors. Low bone mineral density (BMD) and BMD-related and BMD-independent geometric components of bone strength, evaluated by hip strength analysis (HSA) and finite element analysis analyses on dual-energy X-ray absorptiometry (DXA) images, and ultrasound parameters are related to the presence and incidence of hip fracture. In addition, clinical risk factors contribute to the risk of hip fractures, independent of BMD. They are included in the fracture risk assessment tool (FRAX) case finding algorithm to estimate in the individual patient the 10-year risk of hip fracture, with and without BMD. Fall risks are not included in FRAX, but are included in other case finding tools, such as the Garvan algorithm, to predict the 5- and 10-year hip fracture risk. Hormones, cytokines, growth factors, markers of bone resorption and genetic background have been related to hip fracture risk. Vitamin D deficiency is endemic worldwide and low serum levels of 25-hydroxyvitamin D [25(OH)D] predict hip fracture risk. In the context of hip fracture prevention calculation of absolute fracture risk using clinical risks, BMD, bone geometry and fall-related risks is feasible, but needs further refinement by integrating bone and fall-related risk factors into a single case finding algorithm for clinical use.
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Registered trials
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