ArticleTherapeutic advances in musculoskeletal disease2009
Focusing osteoarthritis management on modifiable risk factors and future therapeutic prospects.
Article in Therapeutic advances in musculoskeletal disease, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Partial bodyweight-supported squats elicit eccentric contraction of the thigh muscles.BMC musculoskeletal disorders · 2026Article
- Article
- Do age, gender, BMI and disease duration influence the clinical outcomes in patients of knee osteoarthritis treated with serial injections of autologous platelet rich plasma?Journal of clinical orthopaedics and trauma · 2023Article
- Obesity is related to incidence of patellofemoral osteoarthritis: the Cohort Hip and Cohort Knee (CHECK) study.Rheumatology international · 2020Article
- Modifiable risk factors in knee osteoarthritis: treatment implications.Rheumatology international · 2019Review
- Early improvement in physical activity and function after total hip arthroplasty: Predictors of outcomes.Turkish journal of physical medicine and rehabilitation · 2019Article
- An analysis of 3D knee kinematic data complexity in knee osteoarthritis and asymptomatic controls.PloS one · 2018Article
- Pharmacologic therapy for osteoarthritis--the era of disease modification.Nature reviews. Rheumatology · 2011Review
- Modifiable lifestyle factors are associated with lower pain levels in adults with knee osteoarthritis.Pain research & managementArticle
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathogenesis of osteoarthritis (OA) appears to be the result of a complex interplay between mechanical, cellular, and biochemical forces. Obesity is the strongest risk factor for disease onset and mechanical factors dominate the risk for disease progression. This narrative review focuses on the influence of biomechanics and obesity on the etiology of OA and its symptomatic presentation. We need to revisit the way we currently manage the disease and focus on the modifiable, primarily through nonpharmacologic intervention. Greater therapeutic attention to the important role of mechanical factors and obesity in OA etiopathogenesis is required if we are to find ways of reducing the public health impact of this condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.