ArticleOpen biology2012
AdpA, key regulator for morphological differentiation regulates bacterial chromosome replication.
Article in Open biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Colony politics to chemical warfare: phenotypic plasticity in Streptomyces.Essays in biochemistry · 2026Review
- AdpA, a Global Regulator of Hundreds of Genes, Including Those for Secondary Metabolism, inAntibiotics (Basel, Switzerland) · 2025Article
- AdpA, a developmental regulator, promotes ε-poly-L-lysine biosynthesis in Streptomyces albulus.Microbial cell factories · 2022Article
- Genetic Engineering ofMicroorganisms · 2021Article
- AdpA Positively Regulates Morphological Differentiation and Chloramphenicol Biosynthesis in Streptomyces venezuelae.Microbiology spectrum · 2021Article
- AfsK-Mediated Site-Specific Phosphorylation Regulates DnaA Initiator Protein Activity in Streptomyces coelicolor.Journal of bacteriology · 2020Article
- A Novel AdpA Homologue Negatively Regulates Morphological Differentiation in Streptomyces xiamenensis 318.Applied and environmental microbiology · 2019Article
- Changing Perspectives on the Role of DnaA-ATP in Orisome Function and Timing Regulation.Frontiers in microbiology · 2019Review
- Synchronous termination of replication of the two chromosomes is an evolutionary selected feature in Vibrionaceae.PLoS genetics · 2018Article
- Cyclic Dinucleotide-Controlled Regulatory Pathways in Streptomyces Species.Journal of bacteriology · 2016Review
- c-di-GMP signalling and the regulation of developmental transitions in streptomycetes.Nature reviews. Microbiology · 2015Review
- The adpA-like regulatory gene from Actinoplanes teichomyceticus: in silico analysis and heterologous expression.World journal of microbiology & biotechnology · 2015Article
- The orisome: structure and function.Frontiers in microbiology · 2015Review
- Fifty years after the replicon hypothesis: cell-specific master regulators as new players in chromosome replication control.Journal of bacteriology · 2014Review
- Propionate represses the dnaA gene via the methylcitrate pathway-regulating transcription factor, PrpR, in Mycobacterium tuberculosis.Antonie van Leeuwenhoek · 2014Article
- Developmental biology of Streptomyces from the perspective of 100 actinobacterial genome sequences.FEMS microbiology reviews · 2014Review
- Angucyclines as signals modulate the behaviors of Streptomyces coelicolor.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- oriC-encoded instructions for the initiation of bacterial chromosome replication.Frontiers in microbiology · 2014Review
- Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin.Open biology · 2013Article
- Molecular regulation of antibiotic biosynthesis in streptomyces.Microbiology and molecular biology reviews : MMBR · 2013Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AdpA, one of the most pleiotropic transcription regulators in bacteria, controls expression of several dozen genes during Streptomyces differentiation. Here, we report a novel function for the AdpA protein: inhibitor of chromosome replication at the initiation stage. AdpA specifically recognizes the 5' region of the Streptomyces coelicolor replication origin (oriC). Our in vitro results show that binding of AdpA protein decreased access of initiator protein (DnaA) to the oriC region. We also found that mutation of AdpA-binding sequences increased the accessibility of oriC to DnaA, which led to more frequent replication and acceleration of Streptomyces differentiation (at the stage of aerial hyphae formation). Moreover, we also provide evidence that AdpA and DnaA proteins compete for oriC binding in an ATP-dependent manner, with low ATP levels causing preferential binding of AdpA, and high ATP levels causing dissociation of AdpA and association of DnaA. This would be consistent with a role for ATP levels in determining when aerial hyphae emerge.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.