ArticlePloS one2012
Canine hepacivirus NS3 serine protease can cleave the human adaptor proteins MAVS and TRIF.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Natural Hepacivirus Infection in Tree Shrews: A Call for Routine Screening in Hepatitis Virus Research.Viruses · 2025Article
- Detection and characterization of bovine hepacivirus in cattle and sheep from Hulunbuir, northeastern China.Frontiers in cellular and infection microbiology · 2025Article
- Identification of pigeon mitochondrial antiviral signaling protein (MAVS) and its role in antiviral innate immunity.Archives of virology · 2024Article
- Animal Models of Hepatitis C Virus Infection.Cold Spring Harbor perspectives in medicine · 2020Review
- Evolutionary biology of human hepatitis viruses.Journal of hepatology · 2019Review
- Low level expression of the Mitochondrial Antiviral Signaling protein (MAVS) associated with long-term nonprogression in SIV-infected rhesus macaques.Virology journal · 2018Article
- NS2 proteases from hepatitis C virus and related hepaciviruses share composite active sites and previously unrecognized intrinsic proteolytic activities.PLoS pathogens · 2018Article
- Immune protection against reinfection with nonprimate hepacivirus.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Hepacivirus NS3/4A Proteases Interfere with MAVS Signaling in both Their Cognate Animal Hosts and Humans: Implications for Zoonotic Transmission.Journal of virology · 2016Article
- The Strange, Expanding World of Animal Hepaciviruses.Annual review of virology · 2016Review
- Ion Channel Function and Cross-Species Determinants in Viral Assembly of Nonprimate Hepacivirus p7.Journal of virology · 2016Article
- Evolutionary and Phylogenetic Analysis of the Hepaciviruses and Pegiviruses.Genome biology and evolution · 2015Article
- Porcine reproductive and respiratory syndrome virus 3C protease cleaves the mitochondrial antiviral signalling complex to antagonize IFN-β expression.The Journal of general virology · 2015Article
- Assessment of cross-species transmission of hepatitis C virus-related non-primate hepacivirus in a population of humans at high risk of exposure.The Journal of general virology · 2015Article
- Surveying the global virome: identification and characterization of HCV-related animal hepaciviruses.Antiviral research · 2015Review
- Characterization of nonprimate hepacivirus and construction of a functional molecular clone.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- NS2 proteins of GB virus B and hepatitis C virus share common protease activities and membrane topologies.Journal of virology · 2014Article
- Virus ecology: a gap between detection and prediction.Emerging microbes & infections · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Canine hepacivirus (CHV) was recently identified in domestic dogs and horses. The finding that CHV is genetically the virus most closely related to hepatitis C virus (HCV) has raised the question of whether HCV might have evolved as the result of close contact between dogs and/or horses and humans. The aim of this study was to investigate whether the NS3/4A serine protease of CHV specifically cleaves human mitochondrial antiviral signaling protein (MAVS) and Toll-IL-1 receptor domain-containing adaptor inducing interferon-beta (TRIF). The proteolytic activity of CHV NS3/4A was evaluated using a bacteriophage lambda genetic screen. Human MAVS- and TRIF-specific cleavage sites were engineered into the lambda cI repressor. Upon infection of Escherichia coli cells coexpressing these repressors and a CHV NS3/4A construct, lambda phage replicated up to 2000-fold more efficiently than in cells expressing a CHV protease variant carrying the inactivating substitution S139A. Comparable results were obtained when several HCV NS3/4A constructs of genotype 1b were assayed. This indicates that CHV can disrupt the human innate antiviral defense signaling pathway and suggests a possible evolutionary relationship between CHV and HCV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.