ArticlePloS one2012
Evidence of melanoma in wild marine fish populations.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 98 citations in OpenAlex.
- Melanoma and Other Melanistic Lesions in Brown Bullhead Ameiurus nebulosus From Waterbodies in the Northeastern United States and Canada: Identification of Risk Factors.Journal of fish diseases · 2026Article
- Rare Case of Hypermelanosis or Chromatophore Hyperplasia in Incidental Terapon jarbua (Forsskål, 1775) From a Brackish Water Aquaculture Pond.Journal of fish diseases · 2026Article
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- Novel Adomaviruses Associated with Blotchy Bass Syndrome in Black Basses (bioRxiv : the preprint server for biology · 2025Article
- Novel adomaviruses associated with blotchy bass syndrome in black basses (Micropterus spp.).PloS one · 2025Article
- Efficacy of quercetin in ameliorating hypoxia-induced hematological and histopathological alterations in rohu Labeo rohita.Fish physiology and biochemistry · 2024Article
- Marine Compounds for Melanoma Treatment and Prevention.International journal of molecular sciences · 2022Review
- Gular Cutaneous Fibrosarcoma and Anatomophysiological Considerations for Anaesthesia in a Saddled Bichir,Case reports in veterinary medicine · 2022Article
- Peripheral Nerve Sheath Tumors Resembling Human Atypical Neurofibroma in Goldfish (Animals : an open access journal from MDPI · 2021Article
- Review
- Spontaneously occurring melanoma in animals and their relevance to human melanoma.The Journal of pathology · 2020Review
- Article
- From fish bowl to bedside: The power of zebrafish to unravel melanoma pathogenesis and discover new therapeutics.Pigment cell & melanoma research · 2017Review
- Melanoma and brown seaweed: an integrative hypothesis.Journal of applied phycology · 2017Article
- Comparative Aspects of Canine Melanoma.Veterinary sciences · 2016Review
- Article
- Article
- Ultraviolet-B wavelengths regulate changes in UV absorption of cleaner fish Labroides dimidiatus mucus.PloS one · 2013Article
- Whales use distinct strategies to counteract solar ultraviolet radiation.Scientific reports · 2013Article
Corrections and comments
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Authors and funding
6 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increase in reports of novel diseases in a wide range of ecosystems, both terrestrial and marine, has been linked to many factors including exposure to novel pathogens and changes in the global climate. Prevalence of skin cancer in particular has been found to be increasing in humans, but has not been reported in wild fish before. Here we report extensive melanosis and melanoma (skin cancer) in wild populations of an iconic, commercially-important marine fish, the coral trout Plectropomus leopardus. The syndrome reported here has strong similarities to previous studies associated with UV induced melanomas in the well-established laboratory fish model Xiphophorus. Relatively high prevalence rates of this syndrome (15%) were recorded at two offshore sites in the Great Barrier Reef Marine Park (GBRMP). In the absence of microbial pathogens and given the strong similarities to the UV-induced melanomas, we conclude that the likely cause was environmental exposure to UV radiation. Further studies are needed to establish the large scale distribution of the syndrome and confirm that the lesions reported here are the same as the melanoma in Xiphophorus, by assessing mutation of the EGFR gene, Xmrk. Furthermore, research on the potential links of this syndrome to increases in UV radiation from stratospheric ozone depletion needs to be completed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.