Trial reportPloS one2012
Multiple sclerosis and CCSVI: a population-based case control study.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Association between chronic cerebrospinal venous insufficiency and multiple sclerosis: a systematic review and meta-analysis.BMJ open · 2023Pooled it
- Multimodal noninvasive and invasive imaging of extracranial venous abnormalities indicative of CCSVI: results of the PREMiSe pilot study.BMC neurology · 2013Trial
- No association between variations in extracranial venous anatomy and clinical outcomes in multiple sclerosis patients over 5 years.BMC neurology · 2019Observational
- Evaluation of hemodynamic properties of cerebral venous drainage in patients with multiple sclerosis: a case-control study.Polish journal of radiology · 2014Article
- Is there any relation between chronic cerebrospinal venous insufficiency and multiple sclerosis? - a critical review.Polish journal of radiology · 2014Review
- Potential involvement of the extracranial venous system in central nervous system disorders and aging.BMC medicine · 2013Review
- No evidence for impairment of venous hemodynamics in children or young adults with pediatric-onset multiple sclerosis.AJNR. American journal of neuroradiology · 2013Article
- Article
- Cognitive impairment and "invisible symptoms" are not associated with CCSVI in MS.BMC neurology · 2013Article
- The role of noninvasive and invasive diagnostic imaging techniques for detection of extra-cranial venous system anomalies and developmental variants.BMC medicine · 2013Review
- What went wrong? The flawed concept of cerebrospinal venous insufficiency.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Review
- Chronic cerebrospinal venous insufficiency is not associated with multiple sclerosis and its severity: a blind-verified study.PloS one · 2013Article
- Cerebrospinal Fluid Dynamics in Patients with Multiple Sclerosis: The Role of Phase-Contrast MRI in the Differential Diagnosis of Active and Chronic Disease.Korean journal of radiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic cerebrospinal venous insufficiency (CCSVI) has been associated to multiple sclerosis (MS).
objectiveTo evaluate the possible association between CCSVI and MS, using a population-based control design.
methodsA random cohort of 148 incident MS patients were enrolled in the study. We have also studied 20 patients with clinically isolated syndrome (CIS), 40 patients with other neurological diseases (OND), and 172 healthy controls. Transcranial (TCC) and Echo Color Doppler (ECD) were carried out in 380 subjects. A subject was considered CCSVI positive if ≥2 venous hemodynamic criteria were fulfilled.
resultsCCSVI was present in 28 (18.9%) of the MS patients, in 2 (10%) of CIS patients, in 11 (6.4%) of the controls, and in 2 (5%) of the OND patients. A significant association between MS and CCSVI was found with an odds ratio of 3.41 (95% confidence interval 1.63-7.13; p = 0.001). CCSVI was significantly more frequent among MS subjects with a disease duration longer than 144 months (26.1% versus 12.6% of patients with duration shorter than 144 months; p = 0.03) and among patients with secondary progressive (SP) and primary progressive (PP) forms (30.2% and 29.4, respectively) than in patients with relapsing remitting (RR) MS (14.3%). A stronger association was found considering SP and PP forms (age adjusted OR = 4.7; 95% CI 1.83-12.0, p = 0.001); the association was weaker with the RR patients (age adjusted OR = 2.58; 95%CI 1.12-5.92; p = 0.02) or not significant in CIS group (age adjusted OR = 2.04; 95%CI 0.40-10.3; p = 0.4).
conclusionsA higher frequency of CCSVI has been found in MS patients; it was more evident in patients with advanced MS, suggesting that CCSVI could be related to MS disability.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.