ArticlePLoS biology2012
The evolutionary consequences of blood-stage vaccination on the rodent malaria Plasmodium chabaudi.
Article in PLoS biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 65 citations in OpenAlex.
- Article
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- Understanding the traits underlying vaccine-driven virulence evolution in malaria parasites.BMC biology · 2025Article
- Experimental evolution of a pathogen confronted with innate immune memory increases variation in virulence.PLoS pathogens · 2025Article
- Pathogen priming alters host transmission potential and predictors of transmissibility in a wild songbird species.mSphere · 2025Article
- Pathogen priming alters host transmission potential and predictors of transmissibility in a wild songbird species.bioRxiv : the preprint server for biology · 2024Article
- Incomplete immunity in a natural animal-microbiota interaction selects for higher pathogen virulence.Current biology : CB · 2024Article
- Pathogen evolution during vaccination campaigns.PLoS biology · 2022Article
- Effects of epistasis and recombination between vaccine-escape and virulence alleles on the dynamics of pathogen adaptation.Nature ecology & evolution · 2022Article
- Experimental evidence for stabilizing selection on virulence in a bacterial pathogen.Evolution letters · 2020Article
- Pathogen transmission from vaccinated hosts can cause dose-dependent reduction in virulence.PLoS biology · 2020Article
- Contrasting evolution of virulence and replication rate in an emerging bacterial pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Refugia and anthelmintic resistance: Concepts and challenges.International journal for parasitology. Drugs and drug resistance · 2019Review
- Adaptive phenotypic plasticity in malaria parasites is not constrained by previous responses to environmental change.Evolution, medicine, and public health · 2019Article
- Why the evolution of vaccine resistance is less of a concern than the evolution of drug resistance.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Resource-driven changes to host population stability alter the evolution of virulence and transmission.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Putting evolution in elimination: Winning our ongoing battle with evolving malaria mosquitoes and parasites.Evolutionary applications · 2018Review
- Incomplete host immunity favors the evolution of virulence in an emergent pathogen.Science (New York, N.Y.) · 2018Article
- Reconciling Pasteur and Darwin to control infectious diseases.PLoS biology · 2018Article
- Phenotypic plasticity in reproductive effort: malaria parasites respond to resource availability.Proceedings. Biological sciences · 2017Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Malaria vaccine developers are concerned that antigenic escape will erode vaccine efficacy. Evolutionary theorists have raised the possibility that some types of vaccine could also create conditions favoring the evolution of more virulent pathogens. Such evolution would put unvaccinated people at greater risk of severe disease. Here we test the impact of vaccination with a single highly purified antigen on the malaria parasite Plasmodium chabaudi evolving in laboratory mice. The antigen we used, AMA-1, is a component of several candidate malaria vaccines currently in various stages of trials in humans. We first found that a more virulent clone was less readily controlled by AMA-1-induced immunity than its less virulent progenitor. Replicated parasites were then serially passaged through control or AMA-1 vaccinated mice and evaluated after 10 and 21 rounds of selection. We found no evidence of evolution at the ama-1 locus. Instead, virulence evolved; AMA-1-selected parasites induced greater anemia in naïve mice than both control and ancestral parasites. Our data suggest that recombinant blood stage malaria vaccines can drive the evolution of more virulent malaria parasites.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.