ArticleProceedings of the National Academy of Sciences of the United States of America2012
North African Jewish and non-Jewish populations form distinctive, orthogonal clusters.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 57 citations in OpenAlex.
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- Genetic analysis and natural history of Parkinson's disease due to the LRRK2 G2019S variant.Brain : a journal of neurology · 2024Article
- Sex-biased admixture and assortative mating shape genetic variation and influence demographic inference in admixed Cabo Verdeans.G3 (Bethesda, Md.) · 2022Article
- Principal Component Analyses (PCA)-based findings in population genetic studies are highly biased and must be reevaluated.Scientific reports · 2022Article
- Human genetic admixture through the lens of population genomics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Reconstructing the history of founder events using genome-wide patterns of allele sharing across individuals.PLoS genetics · 2022Article
- Clinical and genetic spectrums of 413 North African families with inherited retinal dystrophies and optic neuropathies.Orphanet journal of rare diseases · 2022Review
- Common founder BRCA2 pathogenic variants and breast cancer characteristics in Ethiopian Jews.Breast cancer research and treatment · 2022Article
- Ancestral patterns of recessive dystrophic epidermolysis bullosa mutations in Hispanic populations suggest sephardic ancestry.American journal of medical genetics. Part A · 2021Article
- Article
- Haplotype Sharing Provides Insights into Fine-Scale Population History and Disease in Finland.American journal of human genetics · 2018Article
- Genetics and genomic medicine in Tunisia.Molecular genetics & genomic medicine · 2018Article
- The time and place of European admixture in Ashkenazi Jewish history.PLoS genetics · 2017Article
- Clustering of 770,000 genomes reveals post-colonial population structure of North America.Nature communications · 2017Article
- Evidence for prehistoric origins of the G2019S mutation in the North African Berber population.PloS one · 2017Article
- The genetic history of Cochin Jews from India.Human genetics · 2016Article
- Localizing Ashkenazic Jews to Primeval Villages in the Ancient Iranian Lands of Ashkenaz.Genome biology and evolution · 2016Article
- OPTN 691_692insAG is a founder mutation causing recessive ALS and increased risk in heterozygotes.Neurology · 2016Article
Corrections and comments
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Authors and funding
16 authors at 10 institutions in 4 countries.
Funding
Abstract
North African Jews constitute the second largest Jewish Diaspora group. However, their relatedness to each other; to European, Middle Eastern, and other Jewish Diaspora groups; and to their former North African non-Jewish neighbors has not been well defined. Here, genome-wide analysis of five North African Jewish groups (Moroccan, Algerian, Tunisian, Djerban, and Libyan) and comparison with other Jewish and non-Jewish groups demonstrated distinctive North African Jewish population clusters with proximity to other Jewish populations and variable degrees of Middle Eastern, European, and North African admixture. Two major subgroups were identified by principal component, neighbor joining tree, and identity-by-descent analysis-Moroccan/Algerian and Djerban/Libyan-that varied in their degree of European admixture. These populations showed a high degree of endogamy and were part of a larger Ashkenazi and Sephardic Jewish group. By principal component analysis, these North African groups were orthogonal to contemporary populations from North and South Morocco, Western Sahara, Tunisia, Libya, and Egypt. Thus, this study is compatible with the history of North African Jews-founding during Classical Antiquity with proselytism of local populations, followed by genetic isolation with the rise of Christianity and then Islam, and admixture following the emigration of Sephardic Jews during the Inquisition.
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