ArticleMolecular and cellular biology2012
SmD3 regulates intronic noncoding RNA biogenesis.
Article in Molecular and cellular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- SnoRNAs: Exploring Their Implication in Human Diseases.International journal of molecular sciences · 2024Review
- Splicing inactivation generates hybrid mRNA-snoRNA transcripts targeted by cytoplasmic RNA decay.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis.Nature communications · 2021Article
- Death by lipids: The role of small nucleolar RNAs in metabolic stress.The Journal of biological chemistry · 2020Review
- Functional diversity of small nucleolar RNAs.Nucleic acids research · 2020Article
- Long-range function of secreted small nucleolar RNAs that direct 2'-The Journal of biological chemistry · 2018Article
- Nuclear export factor 3 regulates localization of small nucleolar RNAs.The Journal of biological chemistry · 2017Article
- Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment.Journal of lipid research · 2016Review
- Rpl13a small nucleolar RNAs regulate systemic glucose metabolism.The Journal of clinical investigation · 2016Article
- Endoplasmic reticulum stress in obesity and obesity-related disorders: An expanded view.Metabolism: clinical and experimental · 2016Review
- RNASET2 is required for ROS propagation during oxidative stress-mediated cell death.Cell death and differentiation · 2016Article
- Cytosolic accumulation of small nucleolar RNAs (snoRNAs) is dynamically regulated by NADPH oxidase.The Journal of biological chemistry · 2015Article
- Potential role for snoRNAs in PKR activation during metabolic stress.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Accumulation of excess lipid in nonadipose tissues is associated with oxidative stress and organ dysfunction and plays an important role in diabetic complications. To elucidate molecular events critical for lipotoxicity, we used retroviral promoter trap mutagenesis to generate mutant Chinese hamster ovary cell lines resistant to lipotoxic and oxidative stress. A previous report of a mutant from this screen demonstrated that under lipotoxic conditions, small nucleolar RNAs (snoRNAs) in the rpL13a gene accumulate in the cytosol and serve as critical mediators of lipotoxic cell death. We now report a novel, independent mutant in which a single provirus disrupted one allele of the gene encoding the spliceosomal protein SmD3, creating a model of haploinsufficiency. We show that snoRNA expression and the abundance of snoRNA-containing intron lariats are decreased in SmD3 mutant cells, even though haploinsufficiency of SmD3 supports pre-mRNA splicing. The mechanism through which SmD3 regulates the expression of intronic snoRNAs likely involves effects of SmD3 on the levels of small nuclear RNAs (snRNAs) U4 and U5. Our data implicate SmD3 as a critical determinant in the processing of intronic noncoding RNAs in general and as an upstream mediator of metabolic stress response pathways through the regulation of snoRNA expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.