ArticleRespiration; international review of thoracic diseases2013
Spleen size in idiopathic and heritable pulmonary arterial hypertension.
Article in Respiration; international review of thoracic diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Uncoupling Protein 2 and Nitric Oxide Deficiency Favor Glycolytic Pathways and Organ Growth in the Rat Spleen.Current issues in molecular biology · 2026Article
- Impact of the spleen size on short-term prognosis in patients with cardiogenic shock receiving Impella-incorporated temporary mechanical circulatory support.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Article
- Assessing causal associations of blood counts and biochemical indicators with pulmonary arterial hypertension: a Mendelian randomization study and results from national health and nutrition examination survey 2003-2018.Frontiers in endocrinology · 2024Observational
- Cardio-Splenic Relationship in Patients Receiving Trans-Catheter Aortic Valve Replacement.Journal of clinical medicine · 2023Article
- Systemic mapping of organ plasma extravasation at multiple stages of chronic heart failure.Frontiers in physiology · 2023Article
- Morphometric assessment of spleen dimensions and its determinants among individuals living in Arba Minch town, southern Ethiopia.BMC medical imaging · 2021Article
- Loss of PKGIβ/IRAG1 Signaling Causes Anemia-Associated Splenomegaly.International journal of molecular sciences · 2021Article
- Hematopoietic stem cell transplantation alters susceptibility to pulmonary hypertension in Bmpr2-deficient mice.Pulmonary circulationArticle
- A review of imaging modalities in pulmonary hypertension.Annals of thoracic medicineReview
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIt is unknown whether the spleen size correlates with disease severity and outcome in patients with idiopathic and heritable pulmonary arterial hypertension (PAH).
objectivesTo determine the prevalence of splenomegaly in PAH and assess whether it correlates with severity of disease and outcome.
methodsWe identified subjects with either heritable or idiopathic PAH who had Doppler echocardiography, right-heart catheterization and computed tomography (CT) of the chest and/or abdomen that included the spleen.
resultsWe included 62 subjects with a mean age (±SD) of 49 (±15) years; 82% were women. Spleen dimensions were 10 (±3), 6 (±2) and 9 (±2) cm for the craniocaudal length, thickness and width measurements, respectively. The median [interquartile range (IQR)] spleen volume was 344 (225-533) cm3. Splenomegaly was observed in 52-63% of the patients, depending on the formula used. The spleen volume was not associated with clinical, echocardiographic or hemodynamic variables. Spleen volume was not associated with adjusted mortality. We studied the characteristics of the spleen during autopsy in 9 patients with idiopathic PAH who died of right-heart failure. The mean (IQR) spleen weight was 220 (151-325) g. We observed early congestion in all but 2 patients who had chronic congestion.
conclusionsSplenomegaly of predominantly mild degree is common in idiopathic and heritable PAH. However, spleen size was not associated with clinical, echocardiographic, hemodynamic and survival data in these patients.
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