ArticleJournal of the Association for Research in Otolaryngology : JARO2012
Brainstem auditory evoked potentials suggest a role for the ventral cochlear nucleus in tinnitus.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 3 of them syntheses that pooled it.
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Who cites it
118 citing papers in PubMed, 3 syntheses or guidelines pooled it, 241 citations in OpenAlex.
- Brainstem evoked auditory potentials in tinnitus: A best-evidence synthesis and meta-analysis.Frontiers in neurology · 2022Pooled it
- A systematic review on the effect of low-dose radiation on hearing.Radiation and environmental biophysics · 2021Pooled it
- Detecting Noise-Induced Cochlear Synaptopathy by Auditory Brainstem Response in Tinnitus Patients With Normal Hearing Thresholds: A Meta-Analysis.Frontiers in neuroscience · 2021Pooled it
- The auditory sensitivity is increased in tinnitus ears.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Trial
- Short-term test-retest reliability of a few proxy measures of cochlear synaptopathy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Sudden Traumatic Noise Exposure Induces an Altered Wave I in the Auditory Brainstem Response in Human.Audiology & neuro-otology · 2026Article
- Neuroscientific therapies for subjective tinnitus.Journal of Zhejiang University. Science. B · 2026Review
- Differences in auditory brainstem responses between laboratory-reared and wild-caught prairie voles (Microtus ochrogaster).PloS one · 2026Article
- Auditory brainstem responses in two closely related Peromyscus species (Peromyscus leucopus and Peromyscus maniculatus).The Journal of the Acoustical Society of America · 2025Article
- Nrf2 deficiency enhances oxidative stress and promotes susceptibility to tinnitus in mice.Scientific reports · 2025Article
- Objective autonomic signatures of tinnitus and sound sensitivity disorders.Science translational medicine · 2025Article
- Phenotypic changes of auditory nerve fibers after excitotoxicity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Altered auditory brainstem responses are post-acute sequela of SARS-CoV-2 (PASC).Scientific reports · 2025Article
- Hypoactivation of the central auditory system in listeners who are hypertolerant of background noise.Journal of neurophysiology · 2024Article
- The curvature quantification of wave I in auditory brainstem responses detects cochlear synaptopathy in human beings.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Sensory Inhibition and Tinnitus: Measurement of Auditory Gating.Seminars in hearing · 2024Review
- Attention-Modulated Cortical Responses as a Biomarker for Tinnitus.Brain sciences · 2024Article
- The human pupil and face encode sound affect and provide objective signatures of tinnitus and auditory hypersensitivity disorders.bioRxiv : the preprint server for biology · 2024Article
- Auditory brainstem response (ABR) waveform analysis program.MethodsX · 2023Article
- Evidence of cochlear neural degeneration in normal-hearing subjects with tinnitus.Scientific reports · 2023Article
58 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Numerous studies have demonstrated elevated spontaneous and sound-evoked brainstem activity in animal models of tinnitus, but data on brainstem function in people with this common clinical condition are sparse. Here, auditory nerve and brainstem function in response to sound was assessed via auditory brainstem responses (ABR) in humans with tinnitus and without. Tinnitus subjects showed reduced wave I amplitude (indicating reduced auditory nerve activity) but enhanced wave V (reflecting elevated input to the inferior colliculi) compared with non-tinnitus subjects matched in age, sex, and pure-tone threshold. The transformation from reduced peripheral activity to central hyperactivity in the tinnitus group was especially apparent in the V/I and III/I amplitude ratios. Compared with a third cohort of younger, non-tinnitus subjects, both tinnitus, and matched, non-tinnitus groups showed elevated thresholds above 4 kHz and reduced wave I amplitude, indicating that the differences between tinnitus and matched non-tinnitus subjects occurred against a backdrop of shared peripheral dysfunction that, while not tinnitus specific, cannot be discounted as a factor in tinnitus development. Animal lesion and human neuroanatomical data combine to indicate that waves III and V in humans reflect activity in a pathway originating in the ventral cochlear nucleus (VCN) and with spherical bushy cells (SBC) in particular. We conclude that the elevated III/I and V/I amplitude ratios in tinnitus subjects reflect disproportionately high activity in the SBC pathway for a given amount of peripheral input. The results imply a role for the VCN in tinnitus and suggest the SBC pathway as a target for tinnitus treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.