ArticleArchives of neurology2012
Comprehensive search for Alzheimer disease susceptibility loci in the APOE region.
Article in Archives of neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 7 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
72 citing papers in PubMed, 7 syntheses or guidelines pooled it, 109 citations in OpenAlex.
- A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores.Molecular neurodegeneration · 2023Pooled it
- Pharmacogenetics and Pharmacotherapy of Military Personnel Suffering from Post-traumatic Stress Disorder.Current neuropharmacology · 2017Pooled it
- New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.Nature communications · 2016Pooled it
- Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.PLoS genetics · 2014Pooled it
- Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers.Brain imaging and behavior · 2014Pooled it
- Pooled it
- SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.PloS one · 2013Pooled it
- Lorazepam Challenge for Individuals at Varying Genetic Risk for Alzheimer Disease.Alzheimer disease and associated disordersTrial
- PreoperativeFrontiers in bioinformatics · 2026Review
- APOE genotype-specific methylation patterns are linked to Alzheimer disease pathology and estrogen response.Translational psychiatry · 2024Article
- Shared genetic aetiology of Alzheimer's disease and age-related macular degeneration by APOC1 and APOE genes.BMJ neurology open · 2024Article
- Alzheimer's disease cortical morphological phenotypes are associated with TOMM40'523-APOE haplotypes.Neurobiology of aging · 2023Article
- APOE ɛ4 allele and TOMM40-APOC1 variants jointly contribute to survival to older ages.Aging cell · 2022Article
- Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN pathway in Alzheimer's disease pathogenesis.Neurobiology of aging · 2022Article
- APOE4 Status and Cognitive Function in Middle-aged and Elderly People.Balkan journal of medical genetics : BJMG · 2022Article
- Modulation of retinoid-X-receptors differentially regulates expression of apolipoprotein genes apoc1 and apoeb by zebrafish microglia.Biology open · 2022Article
- TOMM40-APOE haplotypes are associated with cognitive decline in non-demented Blacks.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.Nature communications · 2021Article
- Prediction of Alzheimer's disease using multi-variants from a Chinese genome-wide association study.Brain : a journal of neurology · 2021Article
- The TOMM40 '523' polymorphism in disease risk and age of symptom onset in two independent cohorts of Parkinson's disease.Scientific reports · 2021Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 9 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate the association of risk and age at onset (AAO) of Alzheimer disease (AD) with single-nucleotide polymorphisms (SNPs) in the chromosome 19 region including apolipoprotein E (APOE) and a repeat-length polymorphism in TOMM40 (poly-T, rs10524523).
designConditional logistic regression models and survival analysis.
settingFifteen genome-wide association study data sets assembled by the Alzheimer's Disease Genetics Consortium.
participantsEleven thousand eight hundred forty AD cases and 10 931 cognitively normal elderly controls.
main outcome measuresAssociation of AD risk and AAO with genotyped and imputed SNPs located in an 800-Mb region including APOE in the entire Alzheimer's Disease Genetics Consortium data set and with the TOMM40 poly-T marker genotyped in a subset of 1256 cases and 1605 controls.
resultsIn models adjusting for APOE ε4, no SNPs in the entire region were significantly associated with AAO at P.001. Rs10524523 was not significantly associated with AD or AAO in models adjusting for APOE genotype or within the subset of ε3/ε3 subjects.
conclusionsAPOE alleles ε2, ε3, and ε4 account for essentially all the inherited risk of AD associated with this region. Other variants including a poly-T track in TOMM40 are not independent risk or AAO loci.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.