ArticleEpigenetics2012
Characterization of CpG island DNA methylation of impairment-related genes in a rat model of cognitive aging.
Article in Epigenetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- Vagus nerve stimulation (VNS) preventing postoperative cognitive dysfunction (POCD): two potential mechanisms in cognitive function.Molecular and cellular biochemistry · 2025Review
- Predictive network analysis identifies JMJD6 and other potential key drivers in Alzheimer's disease.Communications biology · 2023Article
- Transcriptional changes in the rat brain induced by repetitive transcranial magnetic stimulation.Frontiers in human neuroscience · 2023Article
- Potential mechanism of the Shunaoxin pill for preventing cognitive impairment in type 2 diabetes mellitus.Frontiers in neurology · 2022Article
- DNA methylation patterns and gene expression from amygdala tissue of mature Brahman cows exposed to prenatal stress.Frontiers in genetics · 2022Article
- Human iPSC-Derived Neurons as A Platform for Deciphering the Mechanisms behind Brain Aging.Biomedicines · 2021Review
- Neonatal Sevoflurane Exposure Impairs Learning and Memory by the Hypermethylation of Hippocampal Synaptic Genes.Molecular neurobiology · 2021Article
- Novel DNA methylation marker discovery by assumption-free genome-wide association analysis of cognitive function in twins.Aging cell · 2021Article
- Differential DNA methylation following chemotherapy for breast cancer is associated with lack of memory improvement at one year.Epigenetics · 2020Article
- Improvements to Healthspan Through Environmental Enrichment and Lifestyle Interventions: Where Are We Now?Frontiers in neuroscience · 2020Review
- In Vitro Neuroprotection of Rat Hippocampal Neurons by Manninotriose and Astragaloside IV Against Corticosterone-Induced Toxicity.Molecules (Basel, Switzerland) · 2018Article
- Enhanced postsynaptic inhibitory strength in hippocampal principal cells in high-performing aged rats.Neurobiology of aging · 2018Article
- Epigenetic Regulation of Memory-Therapeutic Potential for Disorders.Current neuropharmacology · 2017Review
- Chemo brain: From discerning mechanisms to lifting the brain fog-An aging connection.Cell cycle (Georgetown, Tex.) · 2017Article
- Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- DNA Methylation of Synaptic Genes in the Prefrontal Cortex Is Associated with Aging and Age-Related Cognitive Impairment.Frontiers in aging neuroscience · 2017Article
- Age-related changes in Egr1 transcription and DNA methylation within the hippocampus.Hippocampus · 2016Article
- Epigenetic modification of PKMζ rescues aging-related cognitive impairment.Scientific reports · 2016Article
- Neurosteroids Involvement in the Epigenetic Control of Memory Formation and Storage.Neural plasticity · 2016Review
- Epigenetic pathways through which experiences become linked with biology.Development and psychopathology · 2015Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cognitive abilities, particularly memory formation, vary substantially in the elderly, with some individuals exhibiting dramatic decline with age while others maintain function well into late life. Epigenetic modifications suggest an intriguing mechanism to account for the range of cognitive outcomes in aging as they are responsive to environmental influences and affect gene transcription in cognitively relevant brain regions. Leveraging a well-characterized rat model of neurocognitive aging that recapitulates the range of outcomes seen in humans, we previously identified gene expression profiles in the CA3 subregion of the hippocampus that distinguish between young and aged subjects as well as between impaired and preserved spatial memory function. To investigate the influence of epigenetics on these profiles, we examined genomic CpG DNA methylation in the promoter regions of three neurophysiologically relevant genes (Gabra5, Hspa5 and Syn1) whose expression levels decrease with age and correlate with spatial memory performance. Consistent with mRNA decreases, DNA methylation increased in aged rats relative to young in CpG dense regions of all target promoters examined. However, no correlation with cognition was found. Focused analysis of the Gabra5 gene found that methylation changes were limited to the CpG island and varied substantially across individual CpGs. Methylation at one CpG correlated with learning and demonstrated a significant difference between memory impaired aged rats and those with intact learning. These data provide evidence that broad age-dependent DNA methylation changes occur in CpG dense promoter regions of cognitively relevant genes but suggest that methylation at single CpGs may be more pertinent to individual cognitive differences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.