ReviewNature reviews. Urology2012
The hormonal control of ejaculation.
Review in Nature reviews. Urology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 187 citations in OpenAlex.
- Management of premature ejaculation: a clinical guideline from the Italian Society of Andrology and Sexual Medicine (SIAMS).Journal of endocrinological investigation · 2021Guideline
- A galanin-positive population of lumbar spinal cord neurons modulates sexual arousal and copulatory behavior in male mice.Nature communications · 2025Article
- Process to radioactive iodine treatment for Graves' hyperthyroidism: condemned or absolved?Journal of endocrinological investigation · 2025Review
- Erectile Dysfunction and Oxidative Stress: A Narrative Review.International journal of molecular sciences · 2025Review
- Reduction of Prostate Cancer Risk: Role of Frequent Ejaculation-Associated Mechanisms.Cancers · 2025Review
- Acquired hypoprolactinemia in men, possible phenotype.Reviews in endocrine & metabolic disorders · 2024Review
- Thyroid disorders and male sexual dysfunction.International journal of impotence research · 2024Review
- Psychoneuroendocrine profiles of unmedicated men with major depressive disorder and associations to treatment effects and sexual side-effects.Neuroscience applied · 2024Article
- Vasopressin V1a receptor and oxytocin receptor regulate murine sperm motility differently.Life science alliance · 2023Article
- Article
- High incidence of sexual dysfunction and timed intercourse was found only in infertile males who with known impairment of sperm quality for a long period: evidence from a hospital-based cross-sectional study.Reproductive biology and endocrinology : RB&E · 2022Article
- Novel Marker for Premature Ejaculation: Serum Leptin Level.Sexual medicine · 2022Article
- High Plasma Oxytocin Levels in Men With Hypersexual Disorder.The Journal of clinical endocrinology and metabolism · 2022Article
- Psychosexual Health and Sexual Medicine in Consultation-Liaison Psychiatry.Indian journal of psychiatry · 2022Article
- Premature Ejaculation and Endocrine Disorders: A Literature Review.The world journal of men's health · 2022Review
- Ejaculatory dysfunction in men with diabetes mellitus.World journal of diabetes · 2021Review
- Physiological and pharmacological impact of oxytocin on epididymal propulsion during the ejaculatory process in rodents and men.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Safety and Effectiveness of Dapoxetine On Demand in Chinese Men With Premature Ejaculation: Results of a Multicenter, Prospective, Open-Label Phase IV Study.Sexual medicine · 2021Article
- 2021 European Thyroid Association Guideline on Thyroid Disorders prior to and during Assisted Reproduction.European thyroid journal · 2021Article
- No evidence for prolactin's involvement in the post-ejaculatory refractory period.Communications biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hormones regulate all aspects of male reproduction, from sperm production to sexual drive. Although emerging evidence from animal models and small clinical studies in humans clearly point to a role for several hormones in controlling the ejaculatory process, the exact endocrine mechanisms are unclear. Evidence shows that oxytocin is actively involved in regulating orgasm and ejaculation via peripheral, central and spinal mechanisms. Associations between delayed and premature ejaculation with hypothyroidism and hyperthyroidism, respectively, have also been extensively documented. Some models suggest that glucocorticoids are involved in the regulation of the ejaculatory reflex, but corresponding data from human studies are scant. Oestrogens regulate epididymal motility, whereas testosterone can affect the central and peripheral aspects of the ejaculatory process. Overall, the data of the endocrine system in regulating the ejaculatory reflex suggest that widely available endocrine therapies might be effective in treating sexual disorders in these men. Indeed, substantial evidence has documented that treatments of thyroid diseases are able to improve some ejaculatory difficulties.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.