Evidence map›Paper›PMID 22868664›Full record

ReviewEMBO reports2012

Activation of B cells by non-canonical helper signals.

Andrea Cerutti, Montserrat Cols, Irene Puga

Abstract readReview
In one paragraph

Review in EMBO reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. T and B Cells in Periodontal Disease: New Functions in A Complex Scenario.International journal of molecular sciences · 2019
    Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. B Cells, Antibodies, and More.Clinical journal of the American Society of Nephrology : CJASN · 2016
    Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andrea CeruttiCatalan Institute for Research and Advanced Studies (ICREA), Barcelona Biomedical Research Park, Avenida Dr. Aiguader 88, 08003 Barcelona, Spain.
Montserrat Cols
Irene Puga

Funding

Regulation of IgA class switching in the intestinal mucosaP01AI061093 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2004 to 2021
$29.8M
Role of Follicular T Helper Cells In Enhancing Humoral Immunity and ProtectionU19AI096187 · NIAID · EMORY UNIVERSITY · PI AMARA, RAMA RAO · 2011 to 2015
$26.5M
Regulation of antibody production by innate signalsR01AI057653 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI CERUTTI, ANDREA · 2005 to 2016
$4.3M
Regulation of antibody diversification and production in HIV-1 infectionR01AI074378 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI CERUTTI, ANDREA · 2008 to 2012
$2.1M
Regulation and Function of Immunoglobulin D in Mucosal Immune DefenseU01AI095613 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CERUTTI, ANDREA · 2011 to 2015
$2.1M
NIAID NIH HHS P01 AI061093NIAID NIH HHS R01 AI057653NIAID NIH HHS R01 AI074378NIAID NIH HHS U01 AI095613NIAID NIH HHS U19 AI096187
6 · The paper itself

Abstract

Cognate interaction between T and B lymphocytes of the adaptive immune system is essential for the production of high-affinity antibodies against microbes, and for the establishment of long-term immunological memory. Growing evidence shows that--in addition to presenting antigens to T and B cells--macrophages, dendritic cells and other cells of the innate immune system provide activating signals to B cells, as well as survival signals to antibody-secreting plasma cells. Here, we discuss how these innate immune cells contribute to the induction of highly diversified and temporally sustained antibody responses, both systemically and at mucosal sites of antigen entry.

Indexed as

AnimalsAntibodiesB-LymphocytesDendritic CellsHumansImmunity, InnateLymphocyte ActivationMacrophagesMucous MembraneNatural Killer T-CellsT-Lymphocytes, Helper-InducerAntibodies

Identifiers

PMID22868664
PMCPMC3432803

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.