ArticleExperimental and clinical psychopharmacology2012
Cocaine self-administration in dopamine D₃ receptor knockout mice.
Article in Experimental and clinical psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Dopamine DThe Journal of pharmacology and experimental therapeutics · 2024Article
- HIV gp120 impairs nucleus accumbens neuroimmune function and dopamine D3 receptor-mediated inhibition of cocaine seeking in male rats.Addiction neuroscience · 2023Article
- Identification of the Risk Genes Associated With Vulnerability to Addiction: Major Findings From Transgenic Animals.Frontiers in neuroscience · 2021Review
- 2016 Philip S. Portoghese Medicinal Chemistry Lectureship: Designing Bivalent or Bitopic Molecules for G-Protein Coupled Receptors. The Whole Is Greater Than the Sum of Its Parts.Journal of medicinal chemistry · 2020Article
- Genetic deletion of the dopamine D3 receptor increases vulnerability to heroin in mice.Neuropharmacology · 2018Article
- Article
- Effects of muscarinic MPsychopharmacology · 2018Article
- Effects of Acute and Chronic Treatments with Dopamine DThe Journal of pharmacology and experimental therapeutics · 2017Article
- Regional and source-based patterns of [NeuroImage · 2017Article
- Effects of the GLP-1 Agonist Exendin-4 on Intravenous Ethanol Self-Administration in Mice.Alcoholism, clinical and experimental research · 2016Article
- Opposing effects of dopamine D1- and D2-like agonists on intracranial self-stimulation in male rats.Experimental and clinical psychopharmacology · 2016Article
- Dopamine D₂-Like Receptors and Behavioral Economics of Food Reinforcement.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Differential Roles for Dopamine D1-Like and D2-Like Receptors in Mediating the Reinforcing Effects of Cocaine: Convergent Evidence from Pharmacological and Genetic Studies.Journal of alcoholism and drug dependence · 2015Article
- Loss of feedback inhibition via D2 autoreceptors enhances acquisition of cocaine taking and reactivity to drug-paired cues.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Effects of oral and intravenous administration of buspirone on food-cocaine choice in socially housed male cynomolgus monkeys.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Association of novelty-related behaviors and intravenous cocaine self-administration in Diversity Outbred mice.Psychopharmacology · 2015Article
- Dopamine D1 and D3 receptors mediate reconsolidation of cocaine memories in mouse models of drug self-administration.Neuroscience · 2014Article
- Dopamine D₃ receptor alterations in cocaine-dependent humans imaged with [¹¹C](+)PHNO.Drug and alcohol dependence · 2014Article
- Dopamine D3 and 5-HT1B receptor dysregulation as a result of psychostimulant intake and forced abstinence: Implications for medications development.Neuropharmacology · 2014Review
- Beyond small-molecule SAR: using the dopamine D3 receptor crystal structure to guide drug design.Advances in pharmacology (San Diego, Calif.) · 2014Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
The dopamine D₃ receptor has received attention over the last two decades as a target for medications development for substance abuse disorders. Results have remained mixed. Despite emergence of more D₃-selective ligands, possible attribution of observed effects to D₂ receptors remains a concern. Knockout mice may help shed light on mechanisms. Here we evaluated the effect of constitutive D₃ receptor inactivation ("knockout") on the reinforcing effects of cocaine. We tested D₃ wild-type (WT), heterozygous (D₃⁺/⁻), and knockout (D₃⁻/⁻), mice in acquisition and maintenance of intravenous self-administration across a broad range of cocaine doses, using a fixed ratio (FR) 1 and a progressive ratio (PR) schedule of reinforcement, along with parallel food-reinforced studies. Generally, D₃⁻/⁻ mice showed cocaine self-administration comparable to WT controls across assays. Moderate and nonsignificant trends toward lesser reinforcing effects of a low cocaine dose (0.32 mg/kg) were apparent in acquisition and PR studies, consistent with the idea that the D₃ receptor may play a subtle role in the reinforcing effects of low cocaine doses under low FR conditions. However, those effects with cocaine self-administration were more subtle than the lower responding of D₃ knockout mice observed with food-maintained behavior. In addition, the D₃ antagonist PG01037 failed to affect cocaine self-administration under an FR 1 schedule in WT mice. The present data do not support a necessary role for the D₃ receptor in the direct reinforcing effects of cocaine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.