ArticleBMC clinical pathology2012
Epigenetic regulation of matrix metalloproteinase expression in ameloblastoma.
Article in BMC clinical pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 37 citations in OpenAlex.
- Importance of Metalloproteinase 8 (MMP-8) in the Diagnosis of Periodontitis.International journal of molecular sciences · 2024Review
- Importance of Metalloproteinase Enzyme Group in Selected Skeletal System Diseases.International journal of molecular sciences · 2023Review
- Molecular biological findings of ameloblastoma.The Japanese dental science review · 2021Review
- Epigenetic alterations in ameloblastomas: A literature review.Journal of clinical and experimental dentistry · 2021Review
- Expression of DNMTs and H3K9ac in Ameloblastoma and Ameloblastic Carcinoma.Frontiers in oral health · 2021Article
- Testosterone Depletion Induces Demethylation of Murine Reelin Promoter CpG Dinucleotides: A Preliminary Study.BioMed research international · 2015Article
- S100A8/A9 regulates MMP-2 expression and invasion and migration by carcinoma cells.The international journal of biochemistry & cell biology · 2014Article
- Current concepts and occurrence of epithelial odontogenic tumors: I. Ameloblastoma and adenomatoid odontogenic tumor.Korean journal of pathology · 2013Article
- Kallikrein 4 and matrix metalloproteinase-20 immunoexpression in malignant, benign and infiltrative odontogenic tumors.Journal of oral and maxillofacial pathology : JOMFPArticle
- Immunohistochemical expression of osteonectin, matrix metalloproteinases-9 and Ki-67 in ameloblastoma.Journal of oral and maxillofacial pathology : JOMFPArticle
- Expression level and proteolytic activity of MMP-2 and MMP-9 in dental follicles, dentigerous cysts, odontogenic keratocysts and unicystic ameloblastomas.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelled
backgroundAn ameloblastoma is a benign odontogenic neoplasm with aggressive behaviour and high recurrence rates. The increased expression of matrix metalloproteinases (MMPs) has been reported in ameloblastomas. In the present study, we hypothesised that epigenetic alterations may regulate MMP expression in ameloblastomas.
methodsWe investigated the methylation status of the genes MMP-2 and MMP-9 in addition to mRNA transcription and protein expression in ameloblastomas. Methylation analysis was performed by both methylation-specific polymerase chain reaction (MSP-PCR) and restriction enzyme digestion to evaluate the methylation profile of MMP-2 and MMP-9 in 12 ameloblastoma samples and 12 healthy gingiva fragments, which were included as controls. Furthermore, we investigated the transcription levels of the genes by quantitative reverse-transcription PCR (qRT-PCR). Zymography was performed to verify protein expression in ameloblastomas.
resultsThe ameloblastomas showed a high frequency of unmethylated MMP-2 and MMP-9, whereas the healthy gingival samples presented a sharp prevalence of methylated MMPs. Higher expression levels of MMP-9 were found in ameloblastomas compared to healthy gingiva. However, no significant differences in the MMP-2 mRNA expression between groups was found. All ameloblastomas showed positive expression of MMP-2 and MMP-9 proteins.
conclusionsOur findings suggest that expression of MMP-9 is increased in ameloblastomas and is possibly modulated by unmethylation of the gene.
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Registered trials
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