SynthesisCritical care (London, England)2012
Clinical review: Volume of fluid resuscitation and the incidence of acute kidney injury - a systematic review.
Synthesis in Critical care (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06104020 (Randomized Controlled Trial of Lung Ultrasound-Guided Intraoperative Fluid Management Strategies), which is not on this map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Controlled Trial of Lung Ultrasound-Guided Intraoperative Fluid Management Strategies: Assessing Their Impact on Post-operative Pulmonary Complications and Hemodynamics in Shoulder Arthroscopic Surgerys
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 144 citations in OpenAlex.
- Hemodynamic goal-directed therapy and postoperative kidney injury: an updated meta-analysis with trial sequential analysis.Critical care (London, England) · 2019Pooled it
- Intravascular volume therapy in adults: Guidelines from the Association of the Scientific Medical Societies in Germany.European journal of anaesthesiology · 2016Guideline
- Impact of renal vein doppler ultrasound-guided CVP titration in sepsis: a pilot randomized controlled trial.Critical care (London, England) · 2026Trial
- Trial
- Combining creatinine and volume kinetics identifies missed cases of acute kidney injury following cardiac arrest.Critical care (London, England) · 2013Trial
- Perioperative goal-directed fluid management using noninvasive hemodynamic monitoring in gynecologic oncology.Brazilian journal of anesthesiology (Elsevier)Trial
- Association between renal mean perfusion pressure and prognosis in patients with sepsis-associated acute kidney injury: insights from the MIMIC IV database.Renal failure · 2025Article
- Professor Rinaldo Bellomo: Founder, architect, and choreographer of critical care nephrology.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Review
- Ventilation-induced acute kidney injury in acute respiratory failure: Do PEEP levels matter?Critical care (London, England) · 2025Review
- Ten tips on how to reduce iatrogenic acute kidney injury.Clinical kidney journal · 2025Review
- Article
- Acute kidney injury after non-cardiac major surgery: has it reduced?Clinical kidney journal · 2024Article
- Treatment of Acute Kidney Injury: A Review of Current Approaches and Emerging Innovations.Journal of clinical medicine · 2024Review
- Controlled Mechanical Ventilation in Critically Ill Patients and the Potential Role of Venous Bagging in Acute Kidney Injury.Journal of clinical medicine · 2024Article
- Association between intrarenal venous flow from Doppler ultrasonography and acute kidney injury in patients with sepsis in critical care: a prospective, exploratory observational study.Critical care (London, England) · 2023Observational
- Current Commonly Used Dynamic Parameters and Monitoring Systems for Perioperative Goal-Directed Fluid Therapy: A Review.The Yale journal of biology and medicine · 2023Review
- Low Intra-Abdominal Pressure with Complete Neuromuscular Blockage Reduces Post-Operative Complications in Major Laparoscopic Urologic Surgery: A before-after Study.Journal of clinical medicine · 2022Article
- Intraoperative vasopressor use and early postoperative acute kidney injury in elderly patients undergoing elective noncardiac surgery.Renal failure · 2022Article
- [Comments on the updated German S3 guidelines on intravascular volume therapy in adults].Der Anaesthesist · 2021Review
- Cystatin C predicts long term mortality better than creatinine in a nationwide study of intensive care patients.Scientific reports · 2021Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intravenous fluids are widely administered to maintain renal perfusion and prevent acute kidney injury (AKI). However, fluid overload is of concern during AKI. Using the Pubmed database (up to October 2011) we identified all randomised controlled studies of goal-directed therapy (GDT)-based fluid resuscitation (FR) reporting renal outcomes and documenting fluid given during perioperative care. In 24 perioperative studies, GDT was associated with decreased risk of postoperative AKI (odds ratio (OR) = 0.59, 95% confidence interval (CI) = 0.39 to 0.89) but additional fluid given was limited (median: 555 ml). Moreover, the decrease in AKI was greatest (OR = 0.47, 95% CI = 0.29 to 0.76) in the 10 studies where FR was the same between GDT and control groups. Inotropic drug use in GDT patients was associated with decreased AKI (OR = 0.52, 95% CI = 0.34 to 0.80, P = 0.003), whereas studies not involving inotropic drugs found no effect (OR = 0.75, 95% CI = 0.37 to 1.53, P = 0.43). The greatest protection from AKI occurred in patients with no difference in total fluid delivery and use of inotropes (OR = 0.46, 95% CI = 0.27 to 0.76, P = 0.0036). GDT-based FR may decrease AKI in surgical patients; however, this effect requires little overall FR and appears most effective when supported by inotropic drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.