ArticleJournal of the American Chemical Society2012
C4-alkoxy-HPD: a potent class of synthetic modulators surpassing nature in AI-2 quorum sensing.
Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 30 citations in OpenAlex.
- Activity of Organoboron Compounds against Biofilm-Forming Pathogens.Antibiotics (Basel, Switzerland) · 2024Review
- Tackling Antimicrobial Resistance with Small Molecules Targeting LsrK: Challenges and Opportunities.Journal of medicinal chemistry · 2020Article
- Targeting Quorum Sensing: High-Throughput Screening to Identify Novel LsrK Inhibitors.International journal of molecular sciences · 2019Article
- A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing.Molecules (Basel, Switzerland) · 2018Article
- Focusing quorum sensing signalling by nano-magnetic assembly.Environmental microbiology · 2018Article
- Small molecule inhibitors of AI-2 signaling in bacteria: state-of-the-art and future perspectives for anti-quorum sensing agents.International journal of molecular sciences · 2013Article
- A chemical biology approach to interrogate quorum-sensing regulated behaviors at the molecular and cellular level.Chemistry & biology · 2013Article
- Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activation.Journal of the American Chemical Society · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Bacteria have developed cell-to-cell communication mechanisms, termed quorum sensing (QS), that regulate bacterial gene expression in a cell population-dependent manner. Autoinducer-2 (AI-2), a class of QS signaling molecules derived from (4S)-4,5-dihydroxy-2,3-pentanedione (DPD), has been identified in both Gram-negative and Gram-positive bacteria. Despite considerable interest in the AI-2 QS system, the biomolecular communication used by distinct bacterial species still remains shrouded. Herein, we report the synthesis and evaluation of a new class of DPD analogues, C4-alkoxy-5-hydroxy-2,3-pentanediones, termed C4-alkoxy-HPDs. Remarkably, two of the analogues were more potent QS agonists than the natural ligand, DPD, in Vibrio harveyi. The findings presented extend insights into ligand-receptor recognition/signaling in the AI-2 mediated QS system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.