Evidence map›Paper›PMID 22866934›Full record

ArticleAIDS care2013

Delayed initiation of antiretroviral therapy among HIV-discordant couples in Kenya.

Talia R Kahn, Michelle Desmond, Deepa Rao, Grace E Marx, Brandon L Guthrie, Rose Bosire, Robert Y Choi, James N Kiarie, Carey Farquhar

Abstract read
In one paragraph

Article in AIDS care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Talia R KahnUniversity of Washington School of Medicine, Seattle, WA, USA. Talia.Kahn@ucsf.edu
Michelle Desmond
Deepa Rao
Grace E Marx
Brandon L Guthrie
Rose Bosire
Robert Y Choi
James N Kiarie
Carey Farquhar

Funding

VENEREAL DISEASET32AI007140 · NIAID · UNIVERSITY OF WASHINGTON · PI Julia Cook Dombrowski · 1985 to 2026
$19.4M
INTERNATIONAL TRAINING GRANT IN EPIDEMIOLOGYD43TW000007 · FIC · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY · 1988 to 2012
$16.3M
Northern/Pacific Universities Global Health Research Training ConsortiumR25TW009345 · FIC · UNIVERSITY OF WASHINGTON · PI KOLARS, JOSEPH C., NERURKAR, VIVEK RAMCHANDRA · 2012 to 2016
$5.9M
Protective cellular immune responses in HIV-1 discordant couplesR01AI068431 · NIAID · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY · 2006 to 2010
$3.1M
Institute for Translational Health Science (TL1)TL1RR025016 · NCRR · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2007 to 2011
$2.7M
HIV-1 and Protective Immunity against Common Childhood PathogensK24AI087399 · NIAID · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY · 2010 to 2014
$647k
FIC NIH HHS D43 TW000007FIC NIH HHS R25 TW009345NCRR NIH HHS TL1 RR025016NIAID NIH HHS K24 AI087399NIAID NIH HHS L30 AI097101NIAID NIH HHS R01 AI068431NIAID NIH HHS T32 AI007140
6 · The paper itself

Abstract

Timely initiation of antiretroviral therapy (ART) is particularly important for HIV-discordant couples because viral suppression greatly reduces the risk of transmission to the uninfected partner. To identify issues and concerns related to ART initiation among HIV-discordant couples, we recruited a subset of discordant couples participating in a longitudinal study in Nairobi to participate in in-depth interviews and focus group discussions about ART. Our results suggest that partners in HIV-discordant relationships discuss starting ART, yet most are not aware that ART can decrease the risk of HIV transmission. In addition, their concerns about ART initiation include side effects, sustaining an appropriate level of drug treatment, HIV/AIDS-related stigma, medical/biological issues, psychological barriers, misconceptions about the medications, the inconvenience of being on therapy, and lack of social support. Understanding and addressing these barriers to ART initiation among discordant couples is critical to advancing the HIV "treatment as prevention" agenda.

Indexed as

Health Knowledge, Attitudes, PracticeHIV SerosortingAdultAnti-HIV AgentsDecision MakingFemaleFocus GroupsHIV InfectionsHumansKenyaLongitudinal StudiesMaleMedication AdherenceMiddle AgedSexual PartnersYoung AdultAnti-HIV Agents

Identifiers

PMID22866934
PMCPMC3523215

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.