ArticleACS macro letters2012
Facile Synthesis of Clickable, Water-soluble and Degradable Polyphosphoesters.
Article in ACS macro letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Conformational preorganization of neighbouring groups modulates and expedites polymer self-deconstruction.Nature chemistry · 2026Article
- Thiol-ene Reaction: An Efficient Tool to Design Lipophilic Polyphosphoesters for Drug Delivery Systems.Molecules (Basel, Switzerland) · 2021Article
- Highly-controllable drug release from core cross-linked singlet oxygen-responsive nanoparticles for cancer therapy.RSC advances · 2020Article
- Main-Chain Phosphorus-Containing Polymers for Therapeutic Applications.Molecules (Basel, Switzerland) · 2020Review
- DFT Modeling of Organocatalytic Ring-Opening Polymerization of Cyclic Esters: A Crucial Role of Proton Exchange and Hydrogen Bonding.Polymers · 2019Review
- Stimuli-Responsive Phosphorus-Based Polymers.European journal of inorganic chemistry · 2019Review
- Metabolically Active, Fully Hydrolysable Polymersomes.Angewandte Chemie (International ed. in English) · 2019Article
- Article
- Development of Fully Degradable Phosphonium-Functionalized Amphiphilic Diblock Copolymers for Nucleic Acids Delivery.Biomacromolecules · 2018Article
- Synthetic, Functional Thymidine-Derived Polydeoxyribonucleotide Analogues from a Six-Membered Cyclic Phosphoester.Journal of the American Chemical Society · 2017Article
- Polyphosphazene Based Star-Branched and Dendritic Molecular Brushes.Macromolecular rapid communications · 2016Article
- Poly(ethylene oxide)-block-polyphosphoester-graft-paclitaxel conjugates with acid-labile linkages as a pH-sensitive and functional nanoscopic platform for paclitaxel delivery.Advanced healthcare materials · 2014Article
- Water-Soluble, Biocompatible Polyphosphazenes with Controllable and pH-Promoted Degradation Behavior.Journal of polymer science. Part A, Polymer chemistry · 2014Article
- Surface charges and shell crosslinks each play significant roles in mediating degradation, biofouling, cytotoxicity and immunotoxicity for polyphosphoester-based nanoparticles.Scientific reports · 2013Article
- Polyphosphoester-based cationic nanoparticles serendipitously release integral biologically-active components to serve as novel degradable inducible nitric oxide synthase inhibitors.Advanced materials (Deerfield Beach, Fla.) · 2013Article
- Synthetic Enantiopure Carbohydrate Polymers that are Highly Soluble in Water and Noncytotoxic.ACS macro letters · 2013Article
- Branched Polyphosphazenes with Controlled Dimensions.Journal of polymer science. Part A, Polymer chemistry · 2013Article
- Construction of a Reactive Diblock Copolymer, Polyphosphoester-ACS macro letters · 2013Article
- A Simple and Efficient Synthesis of an Acid-labile Polyphosphoramidate by Organobase-catalyzed Ring-Opening Polymerization and Transformation to Polyphosphoester Ionomers by Acid Treatment.Macromolecules · 2013Article
- Poly(ethylene oxide)-Chemical science · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
"Click" chemistry is a library of efficient and reliable reactions, which have been used to functionalize various classes of bio- and synthetic macromolecular systems for the incorporation of designed properties and functions. In this report, azide-alkyne Huisgen cycloaddition and thiol-yne reactions, two classical "click" chemistries, were employed to functionalize biodegradable, clickable polyphosphoester homopolymers and their water-soluble copolymers. A stable alkyne-functionalized phospholane monomer was synthesized, its organocatalyzed polymerization kinetics were evaluated, and the resulting (co)polymers were utilized to develop this facile method that provides the synthesis of clickable, water-soluble and degradable polyphosphoesters, which can be adapted for various applications.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.