ArticleGenes & cancer2011
Vascular Network Formation in Expanding versus Static Tissues: Embryos and Tumors.
Article in Genes & cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Enhanced endothelial motility and multicellular sprouting is mediated by the scaffold protein TKS4.Scientific reports · 2019Article
- Paper-based Transwell assays: an inexpensive alternative to study cellular invasion.The Analyst · 2018Article
- Soluble VEGFR1 signaling guides vascular patterns into dense branching morphologies.Journal of theoretical biology · 2018Article
- Mast cell hyperactivity underpins the development of oxygen-induced retinopathy.The Journal of clinical investigation · 2017Article
- Applications of computational models to better understand microvascular remodelling: a focus on biomechanical integration across scales.Interface focus · 2015Review
- Active cell and ECM movements during development.Methods in molecular biology (Clifton, N.J.) · 2015Article
- Endothelial cell motility, coordination and pattern formation during vasculogenesis.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
In this perspectives article, we review scientific literature regarding de novo formation of vascular networks within tissues undergoing a significant degree of motion. Next, we contrast dynamic pattern formation in embryos to the vascularization of relatively static tissues, such as the retina. We argue that formation of primary polygonal vascular networks is an emergent process, which is regulated by biophysical mechanisms. Dynamic empirical data, derived from quail embryos, show that vascular beds readily form within a moving extracellular matrix (ECM) microenvironment-which we analogize to the de novo vascularization of small rapidly growing tumors. Our perspective is that the biophysical rules, which govern cell motion during vasculogenesis, may hold important clues to understanding how the first vessels form in certain malignancies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.