ArticleFrontiers in behavioral neuroscience2012
Beyond traditional approaches to understanding the functional role of neuromodulators in sensory cortices.
Article in Frontiers in behavioral neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 64 citations in OpenAlex.
- Locus coeruleus activation transforms cortical taste representations.Cell reports · 2026Article
- Three-factor learning in spiking neural networks: An overview of methods and trends from a machine learning perspective.Patterns (New York, N.Y.) · 2025Review
- Release and Reuptake Sites for Norepinephrine Are Differently Distributed Across Layers of the Primary Visual Cortex in Macaque Monkeys.The Journal of comparative neurology · 2025Article
- Neural processing in the primary auditory cortex following cholinergic lesions of the basal forebrain in ferrets.Hearing research · 2024Article
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- Neural synchrony in cortical networks: mechanisms and implications for neural information processing and coding.Frontiers in integrative neuroscience · 2022Article
- Neuromodulation of the mind-wandering brain state: the interaction between neuromodulatory tone, sharp wave-ripples and spontaneous thought.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Vagus nerve stimulation (VNS)-induced layer-specific modulation of evoked responses in the sensory cortex of rats.Scientific reports · 2020Article
- β-adrenergic modulation of discrimination learning and memory in the auditory cortex.The European journal of neuroscience · 2019Article
- Adenosine AAnatomical record (Hoboken, N.J. : 2007) · 2018Article
- Recollection-related increases in functional connectivity across the healthy adult lifespan.Neurobiology of aging · 2018Article
- Neuromodulation influences synchronization and intrinsic read-out.F1000Research · 2018Article
- Thalamic connections of the core auditory cortex and rostral supratemporal plane in the macaque monkey.The Journal of comparative neurology · 2017Article
- Target bottom-up strength determines the extent of attentional modulations on conscious perception.Experimental brain research · 2017Article
- Neurocognitive factors in sensory restoration of early deafness: a connectome model.The Lancet. Neurology · 2016Review
- Locus Ceruleus Norepinephrine Release: A Central Regulator of CNS Spatio-Temporal Activation?Frontiers in synaptic neuroscience · 2016Article
- Noradrenaline Improves Behavioral Contrast Sensitivity via the β-Adrenergic Receptor.PloS one · 2016Article
- Implications of the Dependence of Neuronal Activity on Neural Network States for the Design of Brain-Machine Interfaces.Frontiers in neuroscience · 2016Article
- Sensory Cortical Plasticity Participates in the Epigenetic Regulation of Robust Memory Formation.Neural plasticity · 2016Review
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1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Over the last two decades, a vast literature has described the influence of neuromodulatory systems on the responses of sensory cortex neurons (review in Gu, 2002; Edeline, 2003; Weinberger, 2003; Metherate, 2004, 2011). At the single cell level, facilitation of evoked responses, increases in signal-to-noise ratio, and improved functional properties of sensory cortex neurons have been reported in the visual, auditory, and somatosensory modality. At the map level, massive cortical reorganizations have been described when repeated activation of a neuromodulatory system are associated with a particular sensory stimulus. In reviewing our knowledge concerning the way the noradrenergic and cholinergic system control sensory cortices, I will point out that the differences between the protocols used to reveal these effects most likely reflect different assumptions concerning the role of the neuromodulators. More importantly, a gap still exists between the descriptions of neuromodulatory effects and the concepts that are currently applied to decipher the neural code operating in sensory cortices. Key examples that bring this gap into focus are the concept of cell assemblies and the role played by the spike timing precision (i.e., by the temporal organization of spike trains at the millisecond time-scale) which are now recognized as essential in sensory physiology but are rarely considered in experiments describing the role of neuromodulators in sensory cortices. Thus, I will suggest that several lines of research, particularly in the field of computational neurosciences, should help us to go beyond traditional approaches and, ultimately, to understand how neuromodulators impact on the cortical mechanisms underlying our perceptual abilities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.