ArticleJournal of bacteriology2012
Genome-wide responses of the model archaeon Halobacterium sp. strain NRC-1 to oxygen limitation.
Article in Journal of bacteriology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Haloarchaea as Promising Chassis to Green Chemistry.Microorganisms · 2024Review
- Genomic Analysis of Haloarchaea from Diverse Environments, including Permian Halite, Reveals Diversity of Ultraviolet Radiation Survival and DNA Photolyase Gene Variants.Microorganisms · 2023Article
- Earliest Photic Zone Niches Probed by Ancestral Microbial Rhodopsins.Molecular biology and evolution · 2022Article
- Bioengineering of Halobacterium sp. NRC-1 gas vesicle nanoparticles with GvpC fusion protein produced in E. coli.Applied microbiology and biotechnology · 2022Article
- The model cyanobacteria Anabaena sp. PCC 7120 possess an intact but partially degenerated gene cluster encoding gas vesicles.BMC microbiology · 2020Article
- Deciphering Pathways for Carotenogenesis in Haloarchaea.Molecules (Basel, Switzerland) · 2020Article
- Acid Experimental Evolution of the HaloarchaeonFrontiers in microbiology · 2020Article
- Extremophilic models for astrobiology: haloarchaeal survival strategies and pigments for remote sensing.Extremophiles : life under extreme conditions · 2020Review
- Global Transcriptional Programs in Archaea Share Features with the Eukaryotic Environmental Stress Response.Journal of molecular biology · 2019Review
- Complex Effects of Cytochrome P450 Monooxygenase on Purple Membrane and Bacterioruberin Production in an Extremely Halophilic Archaeon: Genetic, Phenotypic, and Transcriptomic Analyses.Frontiers in microbiology · 2018Article
- Prokaryotic Community Composition in Arctic Kongsfjorden and Sub-Arctic Northern Bering Sea Sediments As Revealed by 454 Pyrosequencing.Frontiers in microbiology · 2017Article
- Biology and survival of extremely halophilic archaeon Haloarcula marismortui RR12 isolated from Mumbai salterns, India in response to salinity stress.Scientific reports · 2016Article
- Anaerobic Growth of Haloarchaeon Haloferax volcanii by Denitrification Is Controlled by the Transcription Regulator NarO.Journal of bacteriology · 2016Article
- Transcriptional regulation of dimethyl sulfoxide respiration in a haloarchaeon, Haloferax volcanii.Extremophiles : life under extreme conditions · 2016Article
- Antimicrobial Activity and Mechanism of Inhibition of Silver Nanoparticles against Extreme Halophilic Archaea.Frontiers in microbiology · 2016Article
- Haloarchaea and the formation of gas vesicles.Life (Basel, Switzerland) · 2015Review
- On the response of halophilic archaea to space conditions.Life (Basel, Switzerland) · 2014Review
- Community structure and activity of a highly dynamic and nutrient-limited hypersaline microbial mat in Um Alhool Sabkha, Qatar.PloS one · 2014Article
- Cloning, overexpression, purification, and characterization of a polyextremophilic β-galactosidase from the Antarctic haloarchaeon Halorubrum lacusprofundi.BMC biotechnology · 2013Article
- The function of gas vesicles in halophilic archaea and bacteria: theories and experimental evidence.Life (Basel, Switzerland) · 2012Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As part of a comprehensive postgenomic investigation of the model archaeon Halobacterium sp. strain NRC-1, we used whole-genome DNA microarrays to compare transcriptional profiles of cells grown under anaerobic or aerobic conditions. When anaerobic growth supported by arginine fermentation was compared to aerobic growth, genes for arginine fermentation (arc) and anaerobic respiration (dms), using trimethylamine N-oxide (TMAO) as the terminal electron acceptor, were highly upregulated, as was the bop gene, required for phototrophic growth. When arginine fermentation was compared to anaerobic respiration with TMAO, the arc and dms genes were both induced with arginine, while TMAO induced the bop gene and major gas vesicle protein (gvpAC) genes specifying buoyant gas vesicles. Anaerobic conditions with either TMAO or arginine also upregulated the cba genes, encoding one of three cytochrome oxidases. In-frame deletion of two COG3413 family regulatory genes, bat and dmsR, showed downregulation of the bop gene cluster and loss of purple membrane synthesis and downregulation of the dms operon and loss of anaerobic respiration capability, respectively. Bioinformatic analysis identified additional regulatory and sensor genes that are likely involved in the full range of cellular responses to oxygen limitation. Our results show that the Halobacterium sp. has evolved a carefully orchestrated set of responses to oxygen limitation. As conditions become more reducing, cells progressively increase buoyancy, as well as capabilities for phototrophy, scavenging of molecular oxygen, anaerobic respiration, and fermentation.
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