ArticleMacromolecular bioscience2012
Poly(ethylene imine)s as antimicrobial agents with selective activity.
Article in Macromolecular bioscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
73 citing papers in PubMed.
- Beyond Antibiotics: The Role of Antimicrobial Polymers in Modern Therapeutics.Pharmaceutics · 2026Review
- Ultra-High-Throughput Discovery of Multifunctional Polyphenolic Coatings on Droplet Microarrays.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Analysis of the Degradation Pathways, Cytotoxicity, and Antimicrobial Properties of Block Amphiphilic Aliphatic Polyesters Containing Amine and Hydroxyl Groups.Chemistry, an Asian journal · 2026Article
- Branched-chain polyamines: evolutionary adaptation and biotechnological potential.Amino acids · 2026Review
- Triethoxysilyl-Functionalized Polyethylenimine: Its Spontaneous Cross-Linking and Drug Retention.ACS omega · 2026Article
- Alkyl Chain Length Governs Structure, Conformation and Antimicrobial Activity in Poly(alkylene biguanide).Polymers · 2026Article
- A series of quaternary ammonium salt antibacterial agents synthesized and prepared for constructing and screening antibacterial coatings with biosafety on polypropylene.Frontiers in microbiology · 2026Article
- Optimizing Pluronic-PEI Nanocarriers for RNAi Delivery in Oral Cancer: From Polymer Synthesis to Functional Screening.Biomacromolecules · 2025Article
- Hyperbranched Polyethyleneimine-Coordinated Copper(II) Metallopolymers with Preferential Targeting to Prostate Cancer Cells.Pharmaceuticals (Basel, Switzerland) · 2025Article
- The effect of copper on the antifungal activity of polyethyleneimines against quiescent conidia and germlings of Aspergillus nidulans.Scientific reports · 2025Article
- Alkyltriphenylphosphonium-Functionalized Hyperbranched Polyethyleneimine Nanoparticles for Safe and Efficient Bacterial Eradication: A Structure-Property Relationship Study.International journal of molecular sciences · 2025Article
- Toxicity Evaluation of Sulfobetainized Branched Polyethyleneimine via Antibacterial and Biocompatibility Assays.Toxics · 2025Article
- Article
- Synthesis of N-Sulfopropylated Hyperbranched Polyethyleneimine with Enhanced Biocompatibility and Antimicrobial Activity.ChemPlusChem · 2025Article
- Antibacterial Coatings of Poly(ethylenimine)/Poly(l-lactide)-Grafted Hyaluronic Acid Multilayers Surface-Functionalized with Bacteriophages.ACS omega · 2024Article
- Antibiofilm Effects of Modifying Polyvinylidene Fluoride Membranes with Polyethylenimine, Poly(acrylic acid) and Graphene Oxide.Polymers · 2024Article
- Article
- A Simple and Cost-Effective FeClACS applied materials & interfaces · 2024Article
- Regioselective Palladium-Catalyzed Chain-Growth Allylic Amination Polymerization of Vinyl Aziridines.Journal of the American Chemical Society · 2024Article
- Biomaterial-based sponge for efficient and environmentally sound removal of bacteria from water.Scientific reports · 2024Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We report the structure-activity relationship in the antimicrobial activity of linear and branched poly(ethylene imine)s (L- and B-PEIs) with a range of molecular weights (MWs) (500-12,000). Both L- and B-PEIs displayed enhanced activity against Staphylococcus aureus over Escherichia coli. Both B- and L-PEIs did not cause any significant permeabilization of E. coli cytoplasmic membrane. L-PEIs induced depolarization of S. aureus membrane although B-PEIs did not. The low MW B-PEIs caused little or no hemolysis while L-PEIs are hemolytic. The low MW B-PEIs are less cytotoxic to human HEp-2 cells than other PEIs. However, they induced significant cell viability reduction after 24 h incubation. The results presented here highlight the interplay between polymer size and structure on activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.