ArticleJournal of biomedical materials research. Part A2013
Addition of perfluorocarbons to alginate hydrogels significantly impacts molecular transport and fracture stress.
Article in Journal of biomedical materials research. Part A, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Coordination-Driven Assembly of Alginate Networks: From Egg-Box Structures to Bioactive Delivery Applications.Gels (Basel, Switzerland) · 2026Review
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- Silicone cryogel skeletons enhance the survival and mechanical integrity of hydrogel-encapsulated cell therapies.Science advances · 2024Article
- Oxygen-Generating Scaffolds: One Step Closer to the Clinical Translation of Tissue Engineered Products.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2023Article
- Article
- Advances in Skin Wound and Scar Repair by Polymer Scaffolds.Molecules (Basel, Switzerland) · 2021Review
- Optimization of Oxygen Delivery Within Hydrogels.Journal of biomechanical engineering · 2021Review
- Design of Thermoresponsive Polyamine Cross-Linked Perfluoropolyether Hydrogels for Imaging and Delivery Applications.ACS medicinal chemistry letters · 2020Article
- High oxygen preservation hydrogels to augment cell survival under hypoxic condition.Acta biomaterialia · 2020Article
- Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing.International journal of nanomedicine · 2020Review
- An Injectable Oxygen Release System to Augment Cell Survival and Promote Cardiac Repair Following Myocardial Infarction.Scientific reports · 2018Article
- Onion-like multilayered polymer capsules synthesized by a bioinspired inside-out technique.Nature communications · 2017Article
- Recent progress in the use and tracking of transplanted islets as a personalized treatment for type 1 diabetes.Expert review of precision medicine and drug development · 2017Article
- Oxygen Delivering Biomaterials for Tissue Engineering.Journal of materials chemistry. B · 2016Article
- Terminal sterilization of alginate hydrogels: efficacy and impact on mechanical properties.Journal of biomedical materials research. Part B, Applied biomaterials · 2014Article
- Multi-scale multi-mechanism design of tough hydrogels: building dissipation into stretchy networks.Soft matter · 2014Review
- Oxygen Releasing Biomaterials for Tissue Engineering.Polymer international · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Perfluorocarbons (PFCs) are used in biomaterial formulations to increase oxygen (O(2) ) tension and create a homogeneous O(2) environment in three-dimensional tissue constructs. It is unclear how PFCs affect mechanical and transport properties of the scaffold, which are critical for robustness, intracellular signaling, protein transport, and overall device efficacy. In this study, we investigate composite alginate hydrogels containing a perfluorooctyl bromide (PFOB) emulsion stabilized with Pluronic(®) F68 (F68). We demonstrate that PFC addition significantly affects biomaterial properties and performance. Solution and hydrogel mechanical properties and transport of representative hydrophilic (riboflavin), hydrophobic (methyl and ethyl paraben), and protein (bovine serum albumin, BSA) solutes were compared in alginate/F68 composite hydrogels with or without PFOB. Our results indicate that mechanical properties of the alginate/F68/PFOB hydrogels are not significantly affected under small strains, but a significant decrease fracture stress is observed. The effective diffusivity D(eff) of hydrophobic small molecules decreases with PFOB emulsion addition, yet the D(eff) of hydrophilic small molecules remained unaffected. For BSA, the D(eff) increased and the loading capacity decreased with PFOB emulsion addition. Thus, a trade-off between the desired increased O(2) supply provided by PFCs and the mechanical weakening and change in transport of cellular signals must be carefully considered in the design of biomaterials containing PFCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.