ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2013
Sex-specific differences in the association between ABO genotype and gastric cancer risk in a Korean population.
Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Blood groups A and AB are associated with increased gastric cancer risk: evidence from a large genetic study and systematic review.BMC cancer · 2019Pooled it
- Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci.Human molecular genetics · 2016Trial
- Hotspots and trends of risk factors in gastric cancer: A visualization and bibliometric analysis.World journal of gastrointestinal oncology · 2024Article
- No association of ABO blood groups and Rh factor with primary liver cancer in cirrhotic patients: a single-center cross-sectional study.Frontiers in medicine · 2024Article
- Construction and Validation of a Gastric Cancer Diagnostic Model based on Blood Groups and Tumor Markers.Journal of Cancer · 2024Article
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- Association between ABO blood group and risk of Crohn's disease: A case-control study in the Chinese Han population.Journal of clinical laboratory analysis · 2022Article
- Predictive and prognostic effect of ABO blood group on immune checkpoint inhibitors.Cancer biomarkers : section A of Disease markers · 2022Article
- ABO Blood Group Differentials on Survival in Hepatocellular Carcinoma Patients Treated with Chemoembolization.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Prognostic role of ABO blood group and Rhesus factor in cirrhotic patients with hepatocellular carcinoma.Scientific reports · 2019Article
- Epidemiological and genome-wide association study of gastritis or gastric ulcer in korean populations.Genomics & informatics · 2014Article
- Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1.Nature genetics · 2014Article
- Hemostasis, cancer, and ABO blood group: the most recent evidence of association.Journal of thrombosis and thrombolysis · 2014Review
- Clinical and epidemiological profile of cases of deaths from stomach cancer in the National Cancer Institute, Brazil.Ecancermedicalscience · 2014Article
- Article
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10 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough previous studies have demonstrated an association between ABO blood group and the risk of gastric cancer (GC), only one study has identified these associations using the ABO genotype; however, that study did not evaluate sex differences in this association. The aim of the present study was to investigate whether there are sex-specific differences in the ABO genotype-associated risk of GC. In addition, we explored the association of the ABO genotype and the clinicopathologic characteristics of GC in a Korean population.
methodsWe conducted a large-scale case-control study of 3245 GC patients (2204 males, 1041 females) and 1700 controls (821 males, 879 females). The ABO genotype was determined by multicolor real-time polymerase chain reaction (PCR) using displacing probes.
resultsAs compared with genotype OO, genotypes AA and AO in females, but not in males, were associated with a significantly increased risk of GC (odds ratio [OR] 1.56 and 95 % confidence interval [CI] 1.08-2.26 for AA; OR 1.57 and 95 % CI 1.21-2.03 for AO). In a subgroup analysis, blood group A had a significantly increased risk of diffuse-type GC (OR 2.00, 95 % CI 1.43-2.78), but not of intestinal-type (OR 1.31, 95 % CI 0.96-1.79) or mixed-type GC (OR 1.43, 95 % CI 0.92-2.24).
conclusionThe ABO genotypes AA and AO were significantly associated with GC only in females and only for diffuse-type GC. These data suggest that the association between ABO blood group and GC risk may differ according to sex and histological type.
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