Evidence map›Paper›PMID 22865153›Full record

Trial reportQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2013

Prevention of quality-of-life deterioration with light therapy is associated with changes in fatigue in women with breast cancer undergoing chemotherapy.

Neelum Jeste, Lianqi Liu, Michelle Rissling, Vera Trofimenko, Loki Natarajan, Barbara A Parker, Sonia Ancoli-Israel

3 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00478257 nacompletednot on this map

Effect of Increased Light Exposure on Fatigue in Breast Cancer

TypeinterventionalSponsorUniversity of California, San DiegoRan2005 to 2009Enrolled39ConditionsBreast CancerArmsbright white light, comparator red light treatment
NCT02954809 nacompletednot on this mapstarted 2016, after this paper: background citation

Feasibility of Bright Light Therapy on Fatigue, Sleep and Circadian Activity Rhythms in Lung Cancer Survivors

TypeinterventionalSponsorState University of New York at BuffaloRan2016 to 2018Enrolled14ConditionsFatigue, Sleep Disturbance, Circadian DysregulationArmsMorning bright light therapy, Dim light
NCT04525924 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Feasibility Study of Adjunctive Bright Light Therapy (BLT) for Amelioration of Fatigue in Chinese Cancer Patients Admitted to a Palliative Care Unit

TypeinterventionalSponsorHospital Authority, Hong KongRan2020 to 2020Enrolled42ConditionsFatigue, CancerArmsbright light therapy
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 52 citations in OpenAlex.

  1. Trial
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  5. Effects of chronotype-tailored bright light intervention on post-treatment symptoms and quality of life in breast cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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  12. Being in the right place at the right time.Sleep advances : a journal of the Sleep Research Society · 2025
    Article
  13. Review
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  15. Article
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  18. Article
  19. Systems Chronotherapeutics.Pharmacological reviews · 2017
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Neelum JesteDepartment of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive 0733, La Jolla, CA 92093-0733, USA.
Lianqi Liu
Michelle Rissling
Vera Trofimenko
Loki Natarajan
Barbara A Parker
Sonia Ancoli-Israel
University of California, San Diego · USMoores Cancer CenterSan Diego State University · US

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9M
SAN DIEGO CLINICAL AND TRANSLATIONAL RESEARCH INSTITUTEUL1RR031980 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2010 to 2011
$14.0M
UCSD Medical Student Summer Aging Research TrainingT35AG026757 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Benjamin Hyun Han, Ellen Eun-Ok Lee · 2005 to 2026
$2.2M
Contributions of sleep/rhythms/fatigue to chemobrainR01CA112035 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANCOLI-ISRAEL, SONIA · 2005 to 2009
$1.8M
FATIGUE, SLEEP AND CIRCADIAN RHYTHMS IN BREAST CANCERR01CA085264 · NCI · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI ANCOLI-ISRAEL, SONIA · 2000 to 2004
$1.4M
NCI NIH HHS CA112035NCI NIH HHS P30 CA023100NCI NIH HHS P30 CA23100NCI NIH HHS R01 CA085264NCI NIH HHS R01 CA112035NCRR NIH HHS UL1 RR031980NCRR NIH HHS UL1RR031980NIA NIH HHS T35 AG026757NIA NIH HHS T35 AG026757
6 · The paper itself

Abstract

purposeDuring chemotherapy, women with breast cancer not only experience poor quality of life (QOL), they also have little exposure to bright light, which has been shown to be associated with depression, fatigue, and poor sleep in other chronic illnesses. This study examined whether increased light exposure would have a positive effect on QOL.

methodsThirty-nine women with stage I-III breast cancer scheduled to receive ≥ 4 cycles of chemotherapy were randomized to a bright white light (BWL, n = 23) or dim red light (DRL, n = 16) treatment group. Data were collected before (baseline) and during cycles 1 and 4 of chemotherapy. Light was administered via a light box (Litebook(®), Ltd.). QOL was assessed with the Functional Assessment of Cancer Therapy-Breast (FACT-B) and the Functional Outcomes of Sleep Questionnaire (FOSQ).

resultsCompared with baseline, the DRL group demonstrated significant decline in QOL during the treatment weeks of both cycles (all ps < 0.02), whereas the BWL group had no significant decline (all ps > 0.05). Mixed model analyses revealed that there was a group-by-time interaction for FOSQ at the treatment week of cycle 4, and this interaction was mediated by fatigue.

conclusionThe data suggest that increased exposure to bright light during chemotherapy may prevent the decline in QOL via preventing the increase in fatigue.

Indexed as

Quality of LifeAdultAgedAntineoplastic AgentsBreast NeoplasmsDepressionFatigueFemaleHumansLightMiddle AgedNeoplasm StagingPhototherapyPilot ProjectsSurveys and QuestionnairesTime FactorsAntineoplastic Agents

Identifiers

PMID22865153
PMCPMC3780416
OpenAlexW2040057289

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.