ArticleEuropean journal of immunology2012
Cross-reactive responses to modified M1₅₈-₆₆ peptides by CD8⁺ T cells that use noncanonical BV genes can describe unknown repertoires.
Article in European journal of immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Patients with juvenile idiopathic arthritis have decreased clonal diversity in the CD8Frontiers in immunology · 2024Article
- Role of cross-reactivity in cellular immune targeting of influenza A M1Frontiers in immunology · 2022Article
- Pre-existing heterologous T-cell immunity and neoantigen immunogenicity.Clinical & translational immunology · 2020Review
- A Role for Epitope Networking in Immunomodulation by Helminths.Frontiers in immunology · 2018Article
- CDR3 motif generation and selection in the BV19-utilizing subset of the human CD8 T cell repertoire.Molecular immunology · 2016Article
- Extensive T-Cell Epitope Repertoire Sharing among Human Proteome, Gastrointestinal Microbiome, and Pathogenic Bacteria: Implications for the Definition of Self.Frontiers in immunology · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Memory T-cell repertoires are populated by clonotypes selected by an individual's history of antigen exposures. Our previous analysis of middle-age CD8(+) T-cell memory repertoires to the influenza-derived epitope M1(58-66) , described a network of highly cross-reactive BV19 clonotypes responding to M1(58-66) and at least one peptide with a conservative amino acid substitution at either of two TCR contact positions. Here, we report that some substitutions abrogate BV19 responses and favor responses with different BV. Cross-reactive T cells using seven other BV families responded to 12 of 13 peptides tested. BV12 clonotypes define the most extensive cross-reactive network that encompasses seven peptides. We generated 3D networks based on the peptides recognized and BV family used and observed a cluster of five peptides that includes M1(58-66) and another cluster of five peptides that does not include M1(58-66) . The first cluster represents peptides structurally similar to M1(58-66) , and the second represents peptides with more considerable changes in epitope recognition surface. We hypothesize that the second cluster represents the cross-reactive network around another unknown epitope or epitopes. This data supports a model of stable CD8(+) T-cell memory networks that include a substantial contribution from cross-reactive T cells.
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