ArticleImmunogenetics2012
Genome-wide association study identifies TNFSF13 as a susceptibility gene for IgA in a South Chinese population in smokers.
Article in Immunogenetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines.Genome medicine · 2018Trial
- Serum Homocysteine Concentration Is Significantly Associated with Inflammatory/Immune Factors.PloS one · 2015Trial
- Targeting the B-Cell Activating Factor and a Proliferation-Inducing Ligand Pathway in IgAN: From Disease Pathogenesis to Clinical Trial Evidence.Kidney international reports · 2026Review
- Association Between HLA Alleles and IgA Nephropathy in a Taiwanese Population.International journal of molecular sciences · 2026Article
- Genetic Susceptibility to Glomerulonephritis in Children: Analysis of Structural Kidney Genes and Immune System Genes.Journal of clinical medicine · 2025Article
- Whole-exome sequencing in pediatric patients with glomerulonephritis.Frontiers in genetics · 2025Article
- Clinical Application of Polygenic Risk Score in IgA Nephropathy.Phenomics (Cham, Switzerland) · 2024Article
- A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models.The Journal of clinical investigation · 2024Article
- Innate Mechanisms in Selective IgA Deficiency.Frontiers in immunology · 2021Review
- Genome-wide association study identifies new susceptible loci of IgA nephropathy in Koreans.BMC medical genomics · 2019Article
- Association betweenOncotarget · 2017Article
- Multi-factors including Inflammatory/Immune, Hormones, Tumor-related Proteins and Nutrition associated with Chronic Prostatitis NIH IIIa+b and IV based on FAMHES project.Scientific reports · 2017Article
- Identification of sequence variants influencing immunoglobulin levels.Nature genetics · 2017Article
- GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway.PLoS genetics · 2017Article
- Elevated Plasma α-Defensins (HNP1-3) Levels Correlated with IgA1 Glycosylation and Susceptibility to IgA Nephropathy.Disease markers · 2016Article
- IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L.Human molecular genetics · 2014Article
- Cumulative effects of variants identified by genome-wide association studies in IgA nephropathy.Scientific reports · 2014Article
- Immunization associated with erectile dysfunction based on cross-sectional and genetic analyses.PloS one · 2014Article
- Primary glomerulonephritis: A review of important recent discoveries.Kidney research and clinical practice · 2013Review
- The primary glomerulonephritides: a systems biology approach.Nature reviews. Nephrology · 2013Review
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IgA is an important factor in our immune system. There are many diseases associated with it, such as IgA nephropathy, IgA deficiency, and so on. In order to describe the relationship between the genes and the IgA level, we performed a genome-wide association study of serum IgA with 1,999 healthy Chinese men in the first stage and replicated on an independent Chinese sample with 1,496 subjects in the second stage. Association between each SNP with IgA was estimated by multivariate linear regression analysis conditioned on age and smoke. Haplotype analysis for the block around the top SNP was performed. In the first stage, one genomic locus was identified to be significantly associated with IgA. The loci is TNFSF13 (17p13.1; rs3803800; P = 6.26 × 10(-8)). In smoke-specific analysis, rs3803800 was approximately significantly associated with IgA levels in smokers (P = 3.96 × 10(-7)), while no association was observed in nonsmokers (P = 2.28 × 10(-1)). In addition, we performed the haplotype analysis on chromosome 17 with the SNPs around rs3803800. Although the total P value for the haplotype did not acquire significant difference, three haplotypes (TGAG, CACG, and CACA) reached significant (P < 0.05). In conclusion, TNFSF13 could be a susceptible gene which was discovered having relationship with serum IgA level, and smoke might be a factor infecting the IgA level.
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