Evidence map›Paper›PMID 22864921›Full record

ReviewAIDS and behavior2013

MACH14: a multi-site collaboration on ART adherence among 14 institutions.

Honghu Liu, Ira B Wilson, Kathy Goggin, Nancy Reynolds, Jane M Simoni, Carol E Golin, Marc I Rosen, Robert Gross, Glenn Wagner, Robert H Remien and 4 more

Open access · greenAbstract readMulticenter StudyReview
In one paragraph

Review in AIDS and behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
  3. Assessing usual care in clinical trials.Western journal of nursing research · 2015
    Article
  4. Article
  5. Validity of behavioral measures as proxies for HIV-related outcomes.Journal of acquired immune deficiency syndromes (1999) · 2014
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. A closer look at depression and its relationship to HIV antiretroviral adherence.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 13 institutions in 1 country.

Honghu LiuDivision of Public Health and Community Dentistry, School of Dentistry, University of California, Los Angeles, CA, USA. hhliu@ucla.edu
Ira B Wilson
Kathy Goggin
Nancy Reynolds
Jane M Simoni
Carol E Golin
Marc I Rosen
Robert Gross
Glenn Wagner
Robert H Remien
Neil Schneiderman
Judith A Erlen
Julia H Arnsten
David R Bangsberg
Yale University · USBrown University · USColumbia University · USRagon Institute of MGH, MIT and Harvard · USRAND Corporation · USUCLA Health · USUniversity of Miami · USUniversity of Missouri–Kansas City · USUniversity of North Carolina at Chapel Hill · USUniversity of Pennsylvania · USUniversity of Pittsburgh · USUniversity of Washington · USYeshiva University · US

Funding

WOMEN'S HEALTH AGENDAU01AI038858 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI BENSON, CONSTANCE ANN · 1996 to 2008
$157.5M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
The Statistics, Data Science, and Data Management (SDM) CoreP30MH043520 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Claude Ann Mellins · 2003 to 2026
$48.2M
Weill Cornell Medicine - Rutgers New Jersey Medical School Clinical Trials UnitUM1AI069419 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ROY M. GULICK · 2012 to 2026
$44.6M
TB PREVENTION AND HIV IN THE HOMELESS--AN INTERVENTIONR01MH054907 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BANGSBERG, DAVID ROY · 1995 to 2014
$20.7M
HIV-1, ETHNICITY, GENDER AND ACUTE STRESS REACTIVITYP01MH049548 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI IRONSON, GAIL H · 1993 to 2002
$8.5M
Cornell Clinical Trials UnitU01AI069419 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI GULICK, ROY M. · 2007 to 2011
$6.5M
Improving Adherence to Antiretroviral TherapyR01NR004749 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERLEN, JUDITH A · 1998 to 2007
$3.6M
ART Adherence: Observed Therapy and Enhanced CounselingR01MH068197 · NIMH · UNIVERSITY OF MISSOURI KANSAS CITY · PI GOGGIN, KATHY J · 2004 to 2008
$3.6M
A TRAINING INTERVENTION TO ENHANCE ADHERENCE TO HAARTR01MH061695 · NIMH · RAND CORPORATION · PI KANOUSE, DAVID E · 2000 to 2004
$3.2M
Multi-Site Collaborative Study for Adherence Virologic and Clinical OutcomesR01MH078773 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIU, HONGHU · 2007 to 2011
$3.1M
Understanding and Improving Adherence in HIV DiseaseR01DA015679 · NIDA · TUFTS MEDICAL CENTER · PI WILSON, IRA B · 2002 to 2005
$3.0M
NCRR NIH HHS K24 RR020300NIAID NIH HHS AI069419NIAID NIH HHS AI38858NIAID NIH HHS P30 AI050410NIAID NIH HHS R01AI41413NIAID NIH HHS U01 AI069419NIAID NIH HHS UM1 AI069419NIDA NIH HHS K02 DA017277NIDA NIH HHS K02DA017277NIDA NIH HHS R01 DA013826NIDA NIH HHS R01 DA015215NIDA NIH HHS R01 DA015679NIDA NIH HHS R01DA015679NIDA NIH HHS R01DA11869NIDA NIH HHS R01DA13826NIDA NIH HHS R01DA15215NIMH NIH HHS K08 MH001584NIMH NIH HHS K23MH01862NIMH NIH HHS K24 MH092242NIMH NIH HHS P01MH49548NIMH NIH HHS P30 MH043520NIMH NIH HHS R01MH01584NIMH NIH HHS R01 MH054907NIMH NIH HHS R01 MH058986NIMH NIH HHS R01 MH061173NIMH NIH HHS R01 MH061695NIMH NIH HHS R01 MH068197NIMH NIH HHS R01 MH078773NIMH NIH HHS R01MH078773NIMH NIH HHS R01MH54907NIMH NIH HHS R01MH58986NIMH NIH HHS R01 MH61173NIMH NIH HHS R01MH61695NIMH NIH HHS R01MH68197NINR NIH HHS 2R01NR04749NINR NIH HHS R01 NR004749NINR NIH HHS R01NR04749
6 · The paper itself

Abstract

The integration of original data from multiple antiretroviral (ARV) adherence studies offers a promising, but little used method to generate evidence to advance the field. This paper provides an overview of the design and implementation of MACH14, a collaborative, multi-site study in which a large data system has been created for integrated analyses by pooling original data from 16 longitudinal ARV adherence studies. Studies selected met specific criteria including similar research design and data domains such as adherence measured with medication event monitoring system, psychosocial factors related to adherence behavior, and virologic and clinical outcomes. The data system created contains individual data (collected between 1997 and 2009) from 2,860 HIV patients. Collaboration helped resolve the challenges inherent in pooling data across multiple studies, yet produced a data system with strong statistical power and potentially greater capacity to address key scientific questions than possible with single-sample studies or even meta-analytic designs.

Indexed as

Drug MonitoringAdolescentAdultAgedAnti-HIV AgentsClinical Trials as TopicCooperative BehaviorData CollectionFemaleHIV InfectionsHumansInformation SystemsMaleMiddle AgedSocioeconomic FactorsViral LoadAnti-HIV Agents

Identifiers

PMID22864921
PMCPMC3769091
OpenAlexW1969999455

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.