ArticleJournal of the American Society for Mass Spectrometry2012
MALDI in-source decay mass spectrometry of polyamidoamine dendrimers.
Article in Journal of the American Society for Mass Spectrometry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Improving Sensitivity and Resolution of Dendrimer Identification in MALDI-TOF Mass Spectrometry Using Varied Matrix Combinations.Polymers · 2025Article
- Synthesis of Stimuli-Responsive Heterofunctional Dendrimer by Passerini Multicomponent Reaction.ACS omega · 2019Article
- Characterization of Polyamidoamino (PAMAM) Dendrimers Using In-Line Reversed Phase LC Electrospray Ionization Mass Spectrometry.Analytical methods : advancing methods and applications · 2016Article
- Mass spectrometry of dendrimers.Mass spectrometry reviewsReview
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report using MALDI-ISD (in-source decay) mass spectrometry (MS) to characterize highly branched synthetic polymers of polyamidoamine (PAMAM) dendrimer. This inherently monodisperse polymer possesses dendritic branches networked by tertiary amines and an amide functionality in each repeating unit. Among various ISD matrices examined, 2,5-DHB was the most efficient, yielding 33 fragments produced by single- or multiple-bond cleavages. Detailed analysis revealed that cleavages at tertiary amine sites (S- and E-type fragments) were the most pronounced, with various other cleavages around amide groups. The fragmentation mechanism appeared to follow the radical-induced dissociation pathway. In addition, the matrix dependence of PAMAM MALDI-ISD differed from that of peptides/proteins. The observed fragments provided rich structural information, which was suitable to characterize dendritic polymers.
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Registered trials
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