Trial reportAnnals of surgical oncology2012
The unique clinical characteristics of melanoma diagnosed in children.
Trial report in Annals of surgical oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Metastatic melanoma in an infant: neoadjuvant radiotherapy and radical neck dissection.Acta oncologica (Stockholm, Sweden) · 2026Article
- Cutaneous Melanoma in Adolescents and Young Adults Versus Older Patients: Clinical and Histopathological Differences in Western Romania.Dermatopathology (Basel, Switzerland) · 2026Article
- Feasibility of a prospective pediatric melanocytic tumor clinical trial: A report of multidisciplinary clinician survey data from the Children's Oncology Group Rare Tumor Committee.Pediatric blood & cancer · 2024Article
- Melanoma in Pediatric and Young Adult Patients.Current oncology reports · 2024Review
- Skin Cancer Segmentation and Classification Using Vision Transformer for Automatic Analysis in Dermatoscopy-Based Noninvasive Digital System.International journal of biomedical imaging · 2024Article
- Article
- Contrasting features of childhood and adolescent melanomas.Pediatric dermatology · 2018Article
- Higher than reported adolescent and young adult clinical trial enrollment during the "Golden Age" of melanoma clinical trials.Cancer medicine · 2018Article
- Clinical and dermoscopic characterization of pediatric and adolescent melanomas: Multicenter study of 52 cases.Journal of the American Academy of Dermatology · 2018Article
- Pathology and genomics of pediatric melanoma: A critical reexamination and new insights.Pediatric blood & cancer · 2018Review
- Sink or Collaborate: How the Immersive Model Has Helped Address Typical Adolescent and Young Adult Barriers at a Single Institution and Kept the Adolescent and Young Adult Program Afloat.Journal of adolescent and young adult oncology · 2017Article
- [Expression of cancer testis (CT) antigens in pediatric and adolescent melanomas].Der Pathologe · 2017Review
- Pediatric Melanoma: A 35-year Population-based Review.Plastic and reconstructive surgery. Global open · 2017Article
- A Case of Pediatric Melanoma: Treatment Considerations in Advanced Disease.Plastic and reconstructive surgery. Global open · 2015Article
- Long-term Survival after Metastatic Childhood Melanoma.Plastic and reconstructive surgery. Global open · 2014Article
- Age as a predictor of sentinel node metastasis among patients with localized melanoma: an inverse correlation of melanoma mortality and incidence of sentinel node metastasis among young and old patients.Annals of surgical oncology · 2014Article
- Controversies in the evaluation and management of atypical melanocytic proliferations in children, adolescents, and young adults.Journal of the National Comprehensive Cancer Network : JNCCN · 2013Article
- Sentinel Node Biopsy in Young Patients with Atypical Melanocytic Tumors of the Head and Neck.OTO openArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundStudies have demonstrated a higher rate of nodal metastases in melanoma of childhood, but there is controversy about the overall prognosis relative to adults. We describe a large single-institution experience with pediatric melanoma and assess prognostic characteristics.
methodsRetrospective review identified 126 patients diagnosed with melanoma at <21 years of age and referred for treatment from 1986 to 2011. Atypical lesions were excluded. Clinicopathologic characteristics were correlated with sentinel lymph node (SLN) status and outcomes.
resultsSLN biopsy was positive in 18 of 62 cases (29 %). Increasing Breslow thickness correlated with a positive SLN (p < 0.05). After a median follow-up of 5 years, there were 27 recurrences and 20 deaths. Positive SLN patients had significantly worse recurrence-free survival (RFS, p < 0.05) and significantly worse melanoma-specific survival (MSS, p = 0.05) compared with negative SLN patients. The 5-year RFS and MSS for positive SLN patients were 59.5 and 77.8 %, compared with 93.7 and 96.8 % for negative SLN patients. Recurrences and melanoma-related deaths were often seen beyond 5 years. No deaths have occurred in patients <12 years, but 9.1 % of patients 12-17 years and 17.2 % of patients 18-20 years died from melanoma (p = 0.291).
conclusionsChildren with melanoma have higher rates of SLN metastases (29 %) than adults with comparable melanomas. Despite the higher incidence of nodal metastases, survival is equal to or better than what is reported for adults. However, long-term follow-up is necessary in this population since recurrences and deaths are often seen beyond 5 years.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.