Tranexamic acid reduces blood transfusion in surgical patients while its effects on thromboembolic events and mortality are uncertain.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. Comparison of the effectiveness and safety of topical versus intravenous tranexamic acid in primary total knee arthroplasty: a meta-analysis of randomized controlled trials.Journal of orthopaedic surgery and research · 2017
   Pooled it
2. Tranexamic acid in a periarticular multimodal cocktail injection for blood management in total knee arthroplasty: a prospective randomized study.BMC musculoskeletal disorders · 2021
   Trial
3. Are The Applications of Tranexamic Acid in Reverse Hybrid Total Knee Arthroplasty (TKA) The Same as Those in Fully Cemented TKA?: A Randomized Controlled Trial.Advances in therapy · 2021
   Trial
4. Multi-route applications of tranexamic acid to reduce blood loss after total knee arthroplasty: a randomized controlled trial.Medicine · 2019
   Trial
5. Efficacy of topical tranexamic acid within a blood-saving programme for primary total hip arthroplasty: a pragmatic, open-label randomised study.Blood transfusion = Trasfusione del sangue · 2018
   Trial
6. What is the Ideal Route of Administration of Tranexamic Acid in TKA? A Randomized Controlled Trial.Clinical orthopaedics and related research · 2017
   Trial
7. Peri-Articular Injection of Tranexamic Acid Reduce Blood Loss and Transfusion Requirement During Total Knee Arthroplasty: A Meta-analysis.Geriatric orthopaedic surgery & rehabilitation · 2022
   Article
8. Efficacy of the Combined Administration of Systemic and Intra-Articular Tranexamic Acid in Total Hip Arthroplasty Secondary to Femoral Neck Fracture: A Retrospective Study.Advances in orthopedics · 2020
   Article
9. Efficacy and safety of systemic tranexamic acid administration in total knee arthroplasty: A case series.International journal of surgery case reports · 2020
   Article
10. Optimal route for administering tranexamic acid in primary unilateral total hip arthroplasty: Results from a multicenter cohort study.British journal of clinical pharmacology · 2019
    Article
11. Effects of topical tranexamic acid during open reduction and internal fixation of acetabular fractures: A retrospective study.Acta orthopaedica et traumatologica turcica · 2019
    Article
12. A comparative, retrospective study of peri-articular and intra-articular injection of tranexamic acid for the management of postoperative blood loss after total knee arthroplasty.BMC musculoskeletal disorders · 2016
    Article
13. TopicalOrthopedic reviews · 2016
    Article
14. Topical tranexamic acid reduces blood loss and transfusion rates in total hip and total knee arthroplasty.The Journal of arthroplasty · 2013
    Article

Corrections and comments

• Comment on
  Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis.2012

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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