ArticleThe EMBO journal2012
DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis.
Article in The EMBO journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 52 citations in OpenAlex.
- Memory processing in neurodevelopmental disorders: linking behavioral, circuits, and molecular scales.Frontiers in cellular neuroscience · 2026Review
- DSCR1 deficiency ameliorates the Aβ pathology of Alzheimer's disease by enhancing microglial activity.Life science alliance · 2023Article
- Quantitative proteomics analysis to assess protein expression levels in the ovaries of pubescent goats.BMC genomics · 2022Article
- Local Translation Across Neural Development: A Focus on Radial Glial Cells, Axons, and Synaptogenesis.Frontiers in molecular neuroscience · 2021Review
- Regulator of Calcineurin (RCAN): Beyond Down Syndrome Critical Region.Molecules and cells · 2020Review
- Expression of Genes Involved in Axon Guidance: How Much Have We Learned?International journal of molecular sciences · 2020Review
- Increased ER-mitochondria tethering promotes axon regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- DSCR1-mediated TET1 splicing regulates miR-124 expression to control adult hippocampal neurogenesis.The EMBO journal · 2019Article
- hnRNP Q Regulates Internal Ribosome Entry Site-MediatedMolecular and cellular biology · 2019Article
- DAP5 increases axonal outgrowth of hippocampal neurons by enhancing the cap-independent translation of DSCR1.4 mRNA.Cell death & disease · 2019Article
- Bio-Inspired Evolutionary Model of Spiking Neural Networks in Ionic Liquid Space.Frontiers in neuroscience · 2019Article
- High-Amplitude Circadian Rhythms inGenetics · 2018Article
- IRES-mediated translation of cofilin regulates axonal growth cone extension and turning.The EMBO journal · 2018Article
- Peptide regulation of cofilin activity in the CNS: A novel therapeutic approach for treatment of multiple neurological disorders.Pharmacology & therapeutics · 2017Review
- Leucine-Rich Repeat Kinase 2 (LRRK2) Stimulates IL-1β-Mediated Inflammatory Signaling through Phosphorylation of RCAN1.Frontiers in cellular neuroscience · 2017Article
- Allele-Specific Phenotype Suggests a Possible Stimulatory Activity of RCAN-1 on Calcineurin inMolecules and cells · 2016Article
- Division of labor in the growth cone by DSCR1.The Journal of cell biology · 2016Article
- DSCR1 is required for both axonal growth cone extension and steering.The Journal of cell biology · 2016Article
- Where Environment Meets Cognition: A Focus on Two Developmental Intellectual Disability Disorders.Neural plasticity · 2016Review
- New Perspectives for the Rescue of Cognitive Disability in Down Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Most common genetic factors known to cause intellectual disability are Down syndrome and Fragile X syndrome. However, the underlying cellular and molecular mechanisms of intellectual disability remain unclear. Recently, dendritic spine dysmorphogenesis and impaired local protein synthesis are posited to contribute to the cellular mechanisms of intellectual disability. Here, we show that Down syndrome critical region1 (DSCR1) interacts with Fragile X mental retardation protein (FMRP) and regulates both dendritic spine morphogenesis and local protein synthesis. Interestingly, decreasing the level of FMRP restores the DSCR1-induced changes in dendritic spine morphology. Our results imply that DSCR1 is a novel regulator of FMRP and that Fragile X syndrome and Down syndrome may share disturbances in common pathways that regulate dendritic spine morphology and local protein synthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.