ArticleThe Journal of clinical investigation2012
When NK cells overcome their lack of education.
Article in The Journal of clinical investigation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- NKG2C+CD57+ natural killer cells with senescent features are induced during cutaneous leishmaniasis and accumulate in patients with lesional healing impairment.Clinical and experimental immunology · 2024Article
- Dysfunctional natural killer cells can be reprogrammed to regain anti-tumor activity.The EMBO journal · 2024Article
- Lirilumab and Avelumab Enhance Anti-HPV+ Cervical Cancer Activity of Natural Killer CellsFrontiers in oncology · 2022Article
- Modulation of NK cells with checkpoint inhibitors in the context of cancer immunotherapy.Cancer immunology, immunotherapy : CII · 2019Review
- NK cell education via nonclassical MHC and non-MHC ligands.Cellular & molecular immunology · 2017Review
- HLA-C levels impact natural killer cell subset distribution and function.Human immunology · 2016Article
- Natural killer cell receptors: alterations and therapeutic targeting in malignancies.Immunologic research · 2016Review
- Targeting NK Cells for Anticancer Immunotherapy: Clinical and Preclinical Approaches.Frontiers in immunology · 2016Review
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Cells of the immune system have evolved various molecular mechanisms to sense their environment and react to alterations of self. NK cells are lymphocytes with effector and regulatory functions, which are remarkably adaptable to changes in self. In a study published in this issue of the JCI, Tarek and colleagues report the clinical benefits of manipulating NK cell adaptation to self in an innovative mAb-based therapy against neuroblastoma (NB). This novel therapeutic strategy should stimulate further research on NK cell therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.