ArticleEnvironmental research2012
Household mold and dust allergens: exposure, sensitization and childhood asthma morbidity.
Article in Environmental research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
40 citing papers in PubMed, 107 citations in OpenAlex.
- Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33.The Journal of allergy and clinical immunology · 2015Trial
- Fungi in Asthma: From Epidemiology and Airway Mycobiome to Molecular Mechanisms and Novel Allergenic Phytopathogens.International journal of molecular sciences · 2026Review
- Concordance between different methods of detecting fungal-specific IgE antibody in asthma.Frontiers in allergy · 2026Article
- Effects of staphylococcal enterotoxin and fungal sensitization on clinical outcomes of asthma.European journal of medical research · 2024Article
- A review of pathogenic airborne fungi and bacteria: unveiling occurrence, sources, and profound human health implication.Frontiers in microbiology · 2024Review
- Effects of different inhalant allergens on lung functions in adult patients with bronchial asthma.Immunity, inflammation and disease · 2023Article
- Impacts of residential indoor air quality and environmental risk factors on adult asthma-related health outcomes in Chicago, IL.Journal of exposure science & environmental epidemiology · 2023Article
- Mind the gap between non-activated (non-aggressive) and activated (aggressive) indoor fungal testing: impact of pre-sampling environmental settings on indoor air readings.UCL open. Environment · 2023Article
- Environmental Exposures Impact Pediatric Asthma Within the School Environment.Immunology and allergy clinics of North America · 2022Review
- Joint association between ambient air pollutant mixture and pediatric asthma exacerbations.Environmental epidemiology (Philadelphia, Pa.) · 2022Article
- Housing environments and asthma outcomes within population-based samples of adults and children in NYC.Preventive medicine · 2022Article
- Indoor exposure to phthalates and polycyclic aromatic hydrocarbons (PAHs) to Canadian children: the Kingston allergy birth cohort.Journal of exposure science & environmental epidemiology · 2022Article
- Multi-Level Socioenvironmental Contributors to Childhood Asthma in New York City: a Cluster Analysis.Journal of urban health : bulletin of the New York Academy of Medicine · 2021Article
- Indoor Microbial Exposures and Chronic Lung Disease: From Microbial Toxins to the Microbiome.Clinics in chest medicine · 2020Review
- The Indoor Environment and Childhood Asthma.Current allergy and asthma reports · 2020Review
- Asthma and Allergies in the School Environment.Clinical reviews in allergy & immunology · 2019Review
- Association between fungal spore exposure in inner-city schools and asthma morbidity.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019Article
- Acculturation is associated with asthma burden and pulmonary function in Latino youth: The GALA II study.The Journal of allergy and clinical immunology · 2019Article
- Inner-City Asthma in Children.Clinical reviews in allergy & immunology · 2019Review
- Storage mite concentrations are underestimated compared to house dust mite concentrations.Experimental & applied acarology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundFew studies address concurrent exposures to common household allergens, specific allergen sensitization and childhood asthma morbidity.
objectiveTo identify levels of allergen exposures that trigger asthma exacerbations in sensitized individuals.
methodsWe sampled homes for common indoor allergens (fungi, dust mites (Der p 1, Der f 1), cat (Fel d 1), dog (Can f 1) and cockroach (Bla g 1)) for levels associated with respiratory responses among school-aged children with asthma (N=1233) in a month-long study. Blood samples for allergy testing and samples of airborne fungi and settled dust were collected at enrollment. Symptoms and medication use were recorded on calendars. Combined effects of specific allergen sensitization and level of exposure on wheeze, persistent cough, rescue medication use and a 5-level asthma severity score were examined using ordered logistic regression.
resultsChildren sensitized and exposed to any Penicillium experienced increased risk of wheeze (odds ratio [OR] 2.12 95% confidence interval [CI] 1.12, 4.04), persistent cough (OR 2.01 95% CI 1.05, 3.85) and higher asthma severity score (OR 1.99 95% CI 1.06, 3.72) compared to those not sensitized or sensitized but unexposed. Children sensitized and exposed to pet allergen were at significantly increased risk of wheeze (by 39% and 53% for Fel d 1>0.12 μg/g and Can f 1>1.2 μg/g, respectively). Increased rescue medication use was significantly associated with sensitization and exposure to Der p 1>0.10 μg/g (by 47%) and Fel d 1>0.12 μg/g (by 32%).
conclusionAsthmatic children sensitized and exposed to low levels of common household allergens Penicillium, Der p 1, Fel d 1 and Can f 1 are at significant risk for increased morbidity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.