ArticleBMC microbiology2012
Phenotypic and genomic analysis of hypervirulent human-associated Bordetella bronchiseptica.
Article in BMC microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
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- Bcr4 Is a Chaperone for the Inner Rod Protein in theMicrobiology spectrum · 2022Article
- A comprehensive resource for Bordetella genomic epidemiology and biodiversity studies.Nature communications · 2022Article
- Infectious keratitis after transepithelial photorefractive keratectomy: A case report.Indian journal of ophthalmology · 2020Article
- Transcriptional Downregulation of a Type III Secretion System under Reducing Conditions in Bordetella pertussis.Journal of bacteriology · 2020Article
- Cytotoxicity of the effector protein BteA was attenuated in Bordetella pertussis by insertion of an alanine residue.PLoS pathogens · 2020Article
- Characterization of a UniqueInternational journal of molecular sciences · 2020Article
- Review
- Differential regulation of type III secretion and virulence genes in Bordetella pertussis and Bordetella bronchiseptica by a secreted anti-σ factor.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Diversity of secretion systems associated with virulence characteristics of the classical bordetellae.Microbiology (Reading, England) · 2015Article
- Comparative analyses of a cystic fibrosis isolate of Bordetella bronchiseptica reveal differences in important pathogenic phenotypes.Infection and immunity · 2014Article
- Characterization of the N-terminal domain of BteA: a Bordetella type III secreted cytotoxic effector.PloS one · 2013Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundB. bronchiseptica infections are usually associated with wild or domesticated animals, but infrequently with humans. A recent phylogenetic analysis distinguished two distinct B. bronchiseptica subpopulations, designated complexes I and IV. Complex IV isolates appear to have a bias for infecting humans; however, little is known regarding their epidemiology, virulence properties, or comparative genomics.
resultsHere we report a characterization of the virulence of human-associated complex IV B. bronchiseptica strains. In in vitro cytotoxicity assays, complex IV strains showed increased cytotoxicity in comparison to a panel of complex I strains. Some complex IV isolates were remarkably cytotoxic, resulting in LDH release levels in A549 cells that were 10- to 20-fold greater than complex I strains. In vivo, a subset of complex IV strains was found to be hypervirulent, with an increased ability to cause lethal pulmonary infections in mice. Hypercytotoxicity in vitro and hypervirulence in vivo were both dependent on the activity of the bsc T3SS and the BteA effector. To clarify differences between lineages, representative complex IV isolates were sequenced and their genomes were compared to complex I isolates. Although our analysis showed there were no genomic sequences that can be considered unique to complex IV strains, there were several loci that were predominantly found in complex IV isolates.
conclusionOur observations reveal a T3SS-dependent hypervirulence phenotype in human-associated complex IV isolates, highlighting the need for further studies on the epidemiology and evolutionary dynamics of this B. bronchiseptica lineage.
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