ArticleSurgery2013
The intestinal environment of surgical injury transforms Pseudomonas aeruginosa into a discrete hypervirulent morphotype capable of causing lethal peritonitis.
Article in Surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 51 citations in OpenAlex.
- Decoding the gut interactome after severe trauma: from molecular dialogue to integrative treatment strategies.Frontiers in microbiology · 2026Review
- The Gut in Critical Illness.Current gastroenterology reports · 2025Review
- Friend or foe: the gut microbiota as a modulator of disease trajectory in trauma, surgery, and critical illness.Gut microbes · 2025Review
- A specific innate immune response silences the virulence of Pseudomonas aeruginosa in a latent infection model in the Drosophila melanogaster host.PLoS pathogens · 2024Article
- Chronic Critical Illness and PICS Nutritional Strategies.Journal of clinical medicine · 2021Review
- Effects of sepsis and its treatment measures on intestinal flora structure in critical care patients.World journal of gastroenterology · 2021Article
- Nutrition in the Neurocritical Care Unit: a New Frontier.Current treatment options in neurology · 2021Review
- Unexpected Cell Wall Alteration-Mediated Bactericidal Activity of the Antifungal Caspofungin against Vancomycin-Resistant Enterococcus faecium.Antimicrobial agents and chemotherapy · 2020Article
- Extended Contact Lens Wear Promotes Corneal Norepinephrine Secretion and Pseudomonas aeruginosa Infection in Mice.Investigative ophthalmology & visual science · 2020Article
- Human Brain Organoids to Decode Mechanisms of Microcephaly.Frontiers in cellular neuroscience · 2020Review
- The gut microbiome alters immunophenotype and survival from sepsis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- The microbiome and nutrition in critical illness.Current opinion in critical care · 2019Review
- Critical illness and the role of the microbiome.Acute medicine & surgery · 2019Review
- Gut integrity in critical illness.Journal of intensive care · 2019Review
- The intestinal microenvironment in sepsis.Biochimica et biophysica acta. Molecular basis of disease · 2017Review
- New insights into the gut as the driver of critical illness and organ failure.Current opinion in critical care · 2017Review
- Pathophysiology of the Gut and the Microbiome in the Host Response.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2017Review
- The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines for management of intra-abdominal infections.World journal of emergency surgery : WJES · 2017Review
- The Influence of Host Stress on the Mechanism of Infection: Lost Microbiomes, Emergent Pathobiomes, and the Role of Interkingdom Signaling.Frontiers in microbiology · 2017Article
- Class I PI3-kinase or Akt inhibition do not impair axonal polarization, but slow down axonal elongation.Biochimica et biophysica acta · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSecondary peritonitis continues to carry a high mortality rate despite the aggressive use of imaging, drainage, and antibiotics. Although host factors and microbial burden contribute to the outcome of peritonitis, we propose a role for bacterial virulence as a determinant of outcome from peritonitis. Bacterial virulence is an inducible trait that is activated in response to specific local "cues" that we have previously shown to be present in the mouse gut exposed to surgical stress and injury.
methodsPseudomonas aeruginosa was harvested after its intestinal inoculation into the cecum of mice subjected to surgical injury (30% hepatectomy) or sham surgery (controls). Harvested strains were then injected into the peritoneum of noninjured (naïve) mice and mortality determined.
resultsP. aeruginosa harvested from the intestines of surgically injured mice caused 100% mortality, whereas strains harvested from control mice caused no mortality. Among recovered strains, a distinct P. aeruginosa morphotype (wrinkled shape) was shown to cause lethal peritonitis compared to smooth-shaped strains, which were nonlethal. Wrinkled strains were associated with a tendency to elicit a more proinflammatory response in mice compared to smooth-shaped strains.
conclusionSurgical injury transforms the morphotype of intestinal P. aeruginosa to express a hypervirulent response in the peritoneum of mice. Enhanced virulence of intestinal pathogens in response to surgical injury may play an important role in predicting the outcome of peritonitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.