ArticleJournal of cellular and molecular medicine2012
Cardiomyocyte Ca2+ handling and structure is regulated by degree and duration of mechanical load variation.
Article in Journal of cellular and molecular medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Review
- Augmenting workload drives T-tubule assembly in developing cardiomyocytes.The Journal of physiology · 2024Article
- Dynamic mechanobiology of cardiac cells and tissues: Current status and future perspective.Biophysics reviews · 2023Review
- Scanning Ion Conductance Microscopy.Chemical reviews · 2021Review
- Review
- The Physiology and Pathophysiology of T-Tubules in the Heart.Frontiers in physiology · 2021Review
- The mechanism of osmotically induced sealing of cardiac t tubules.American journal of physiology. Heart and circulatory physiology · 2020Article
- Myocardial slices come to age: an intermediate complexity in vitro cardiac model for translational research.Cardiovascular research · 2020Review
- Studying signal compartmentation in adult cardiomyocytes.Biochemical Society transactions · 2020Review
- Microtubules regulate cardiomyocyte transversal Young's modulus.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The role of fibroblast - Cardiomyocyte interaction for atrial dysfunction in HFpEF and hypertensive heart disease.Journal of molecular and cellular cardiology · 2019Article
- Diverse relaxation rates exist among rat cardiomyocytes isolated from a single myocardial region.The Journal of physiology · 2019Article
- Mechanical Stretching Simulates Cardiac Physiology and Pathology through Mechanosensor Piezo1.Journal of clinical medicine · 2018Article
- Effect of patterned polyacrylamide hydrogel on morphology and orientation of cultured NRVMs.Scientific reports · 2018Article
- Caveolin 3-dependent loss of t-tubular IExperimental physiology · 2018Article
- Transient activation of PKC results in long-lasting detrimental effects on systolic [CaJournal of molecular and cellular cardiology · 2018Article
- Dyadic Plasticity in Cardiomyocytes.Frontiers in physiology · 2018Review
- Partial Mechanical Unloading of the Heart Disrupts L-Type Calcium Channel and Beta-Adrenoceptor Signaling Microdomains.Frontiers in physiology · 2018Article
- Regulation of Cardiomyocyte T-Tubular Structure: Opportunities for Therapy.Current heart failure reports · 2017Review
- Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis.Cardiovascular research · 2016Article
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Authors and funding
11 authors.
Funding
Abstract
Cardiac transverse (t)-tubules are altered during disease and may be regulated by stretch-sensitive molecules. The relationship between variations in the degree and duration of load and t-tubule structure remains unknown, as well as its implications for local Ca(2+)-induced Ca(2+) release (CICR). Rat hearts were studied after 4 or 8 weeks of moderate mechanical unloading [using heterotopic abdominal heart-lung transplantation (HAHLT)] and 6 or 10 weeks of pressure overloading using thoracic aortic constriction. CICR, cell and t-tubule structure were assessed using confocal-microscopy, patch-clamping and scanning ion conductance microscopy. Moderate unloading was compared with severe unloading [using heart-only transplantation (HAHT)]. Mechanical unloading reduced cardiomyocyte volume in a time-dependent manner. Ca(2+) release synchronicity was reduced at 8 weeks moderate unloading only. Ca(2+) sparks increased in frequency and duration at 8 weeks of moderate unloading, which also induced t-tubule disorganization. Overloading increased cardiomyocyte volume and disrupted t-tubule morphology at 10 weeks but not 6 weeks. Moderate mechanical unloading for 4 weeks had milder effects compared with severe mechanical unloading (37% reduction in cell volume at 4 weeks compared to 56% reduction after severe mechanical unloading) and did not cause depression and delay of the Ca(2+) transient, increased Ca(2+) spark frequency or impaired t-tubule and cell surface structure. These data suggest that variations in chronic mechanical load influence local CICR and t-tubule structure in a time- and degree-dependent manner, and that physiological states of increased and reduced cell size, without pathological changes are possible.
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