ArticleNeuropathology and applied neurobiology2013
Stereological assessment of the dorsal anterior cingulate cortex in schizophrenia: absence of changes in neuronal and glial densities.
Article in Neuropathology and applied neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Glial Cell Abnormalities in Major Psychiatric Diseases: A Systematic Review of Postmortem Brain Studies.Molecular neurobiology · 2022Pooled it
- Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review.Molecular psychiatry · 2016Pooled it
- The deficit of oligodendrocyte family cells in layer 3 of the dorsal anterior cingulate cortex in schizophrenia: possible interactions with dysfunction and altered microanatomy.European archives of psychiatry and clinical neuroscience · 2026Article
- Hyperdynamic microtubule-based structural changes in Monocyte-Derived-Neuronal-like cells from patients with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2026Article
- Deficit of oligodendrocyte family cells in layer 5 of the dorsal anterior cingulate cortex in schizophrenia.European archives of psychiatry and clinical neuroscience · 2026Article
- Glial cell deficits are a key feature of schizophrenia: implications for neuronal circuit maintenance and histological differentiation from classical neurodegeneration.Molecular psychiatry · 2025Review
- Reduced cortical neuron number and neuron density in schizophrenia with focus on area 24: a post-mortem case-control study.European archives of psychiatry and clinical neuroscience · 2023Article
- Neuroimaging in schizophrenia: an overview of findings and their implications for synaptic changes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Decreased Oligodendrocyte Number in Hippocampal Subfield CA4 in Schizophrenia: A Replication Study.Cells · 2022Article
- Astrocyte Activation, but not Microglia, Is Associated with the Experimental Mouse Model of Schizophrenia Induced by Chronic Ketamine.Journal of molecular neuroscience : MN · 2022Article
- Quantitative Macromolecular Proton Fraction Mapping Reveals Altered Cortical Myelin Profile in Schizophrenia Spectrum Disorders.Cerebral cortex communications · 2021Article
- TheJournal of clinical medicine · 2019Review
- Depth-dependent intracortical myelin organization in the living human brain determined by in vivo ultra-high field magnetic resonance imaging.NeuroImage · 2019Article
- A Neural Model of Empathic States in Attachment-Based Psychotherapy.Computational psychiatry (Cambridge, Mass.) · 2017Article
- Optimization of electron microscopy for human brains with long-term fixation and fixed-frozen sections.Acta neuropathologica communications · 2014Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
aimsThe prefrontal and anterior cingulate cortices are implicated in schizophrenia, and many studies have assessed volume, cortical thickness, and neuronal densities or numbers in these regions. Available data, however, are rather conflicting and no clear cortical alteration pattern has been established. Changes in oligodendrocytes and white matter have been observed in schizophrenia, introducing a hypothesis about a myelin deficit as a key event in disease development.
methodsWe investigated the dorsal anterior cingulate cortex (dACC) in 13 men with schizophrenia and 13 age- and gender-matched controls. We assessed stereologically the dACC volume, neuronal and glial densities, total neurone and glial numbers, and glia/neurone index (GNI) in both layers II-III and V-VI.
resultsWe observed no differences in neuronal or glial densities. No changes were observed in dACC cortical volume, total neurone numbers, and total glial numbers in schizophrenia. This contrasts with previous findings and suggests that the dACC may not undergo as severe changes in schizophrenia as is generally believed. However, we observed higher glial densities in layers V-VI than in layers II-III in both controls and patients with schizophrenia, pointing to possible layer-specific effects on oligodendrocyte distribution during development.
conclusionsUsing rigorous stereological methods, we demonstrate a seemingly normal cortical organization in an important neocortical area for schizophrenia, emphasizing the importance of such morphometric approaches in quantitative neuropathology. We discuss the significance of subregion- and layer-specific alterations in the development of schizophrenia, and the discrepancies between post mortem histopathological studies and in vivo brain imaging findings in patients.
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