ArticlePloS one2012
Intense passionate love attenuates cigarette cue-reactivity in nicotine-deprived smokers: an FMRI study.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Neuroimaging craving: urge intensity matters.Addiction (Abingdon, England) · 2015Pooled it
- Preoccupation in an early-romantic relationship predicts experimental pain relief.Pain medicine (Malden, Mass.) · 2014Trial
- Self-Expansion Activities with a Partner as One Path to Well-Being.Behavioral sciences (Basel, Switzerland) · 2026Review
- Toward consistent reporting of sample characteristics in studies investigating the biological mechanisms of romantic love.Frontiers in psychology · 2023Review
- Self-expansion is positively associated with Fitbit-measured daily steps across 4-weeks.Scientific reports · 2022Article
- The Neurobiological Basis of Love: A Meta-Analysis of Human Functional Neuroimaging Studies of Maternal and Passionate Love.Brain sciences · 2022Review
- Proximate and Ultimate Perspectives on Romantic Love.Frontiers in psychology · 2021Review
- Does Love Influence Athletic Performance? The Perspectives of Olympic Athletes.Review of European studies · 2016Article
- Intense, Passionate, Romantic Love: A Natural Addiction? How the Fields That Investigate Romance and Substance Abuse Can Inform Each Other.Frontiers in psychology · 2016Review
- Dissociated effects of anticipating smoking versus monetary reward in the caudate as a function of smoking abstinence.Biological psychiatry · 2014Article
- Prequit fMRI responses to pleasant cues and cigarette-related cues predict smoking cessation outcome.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2014Article
- An fMRI study of nicotine-deprived smokers' reactivity to smoking cues during novel/exciting activity.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
Self-expanding experiences like falling in love or engaging in novel, exciting and interesting activities activate the same brain reward mechanism (mesolimbic dopamine pathway) that reinforces drug use and abuse, including tobacco smoking. This suggests the possibility that reward from smoking is substitutable by self-expansion (through competition with the same neural system), potentially aiding cessation efforts. Using a model of self-expansion in the context of romantic love, the present fMRI experiment examined whether, among nicotine-deprived smokers, relationship self-expansion is associated with deactivation of cigarette cue-reactivity regions. Results indicated that among participants who were experiencing moderate levels of craving, cigarette cue-reactivity regions (e.g., cuneus and posterior cingulate cortex) showed significantly less activation during self-expansion conditions compared with control conditions. These results provide evidence that rewards from one domain (self-expansion) can act as a substitute for reward from another domain (nicotine) to attenuate cigarette cue reactivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.