ArticlePloS one2012
Pertussis circulation has increased T-cell immunity during childhood more than a second acellular booster vaccination in Dutch children 9 years of age.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Robust Humoral and Cellular Immune Responses to Pertussis in Adults After a First Acellular Booster Vaccination.Frontiers in immunology · 2018Trial
- Immunological insights into why pertussis continues to be endemic.Human vaccines & immunotherapeutics · 2026Review
- A semi high-throughput whole blood-based flow cytometry assay to detect and monitorFrontiers in immunology · 2023Article
- Article
- Recent increase in pertussis incidence in Korea: an age-period-cohort analysis.Epidemiology and health · 2021Article
- Whole-Cell or Acellular Pertussis Primary Immunizations in Infancy Determines Adolescent Cellular Immune Profiles.Frontiers in immunology · 2018Article
- What Is Wrong with Pertussis Vaccine Immunity? The Problem of Waning Effectiveness of Pertussis Vaccines.Cold Spring Harbor perspectives in biology · 2017Review
- Rediscovering Pertussis.Frontiers in pediatrics · 2016Review
- The Potential Impact of a Hepatitis C Vaccine for People Who Inject Drugs: Is a Vaccine Needed in the Age of Direct-Acting Antivirals?PloS one · 2016Article
- Waning and aging of cellular immunity to Bordetella pertussis.Pathogens and disease · 2015Review
- Identification of pertussis-specific effector memory T cells in preschool children.Clinical and vaccine immunology : CVI · 2015Article
- Article
- Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Differential T- and B-cell responses to pertussis in acellular vaccine-primed versus whole-cell vaccine-primed children 2 years after preschool acellular booster vaccination.Clinical and vaccine immunology : CVI · 2013Article
- Loss of multi-epitope specificity in memory CD4(+) T cell responses to B. pertussis with age.PloS one · 2013Observational
- T-cell responses before and after the fifth consecutive acellular pertussis vaccination in 4-year-old Dutch children.Clinical and vaccine immunology : CVI · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledHere we report the first evaluation of T-cell responses upon a second acellular pertussis booster vaccination in Dutch children at 9 years of age, 5 years after a preschool booster vaccination. Blood samples of children 9 years of age were studied longitudinally until 1 year after the second aP booster and compared with those after the first aP booster in children 4 and 6 years of age from a cross-sectional study. After stimulation with pertussis-vaccine antigens, Th1, Th2 and Th17 cytokine responses were measured and effector memory cells (CCR7-CD45RA-) were characterized by 8-colour FACS analysis. The second aP booster vaccination at pre-adolescent age in wP primed individuals did increase pertussis-specific Th1 and Th2 cytokine responses. Noticeably, almost all T-cell responses had increased with age and were already high before the booster vaccination at 9 years of age. The enhancement of T-cell immunity during the 5 year following the booster at 4 years of age is probably caused by natural boosting due to the a high circulation of pertussis. However, the incidence of pertussis is high in adolescents and adults who have only received the Dutch wP vaccine during infancy and no booster at 4 years of age. Therefore, an aP booster vaccination at adolescence or later in these populations might improve long-term immunity against pertussis and reduce the transmission to the vulnerable newborns.
trial registrationControlled-Trials.com ISRCTN64117538.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.