ArticlePloS one2012
Cells expressing the C/EBPbeta isoform, LIP, engulf their neighbors.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Biological relevance of cell-in-cell in cancers.Biochemical Society transactions · 2019Review
- Cell-in-cell phenomena in cancer.Nature reviews. Cancer · 2018Review
- Genomic instability in mutant p53 cancer cells upon entotic engulfment.Nature communications · 2018Article
- Consecutive entosis stages in human substrate-dependent cultured cells.Scientific reports · 2017Article
- Article
- Comparative Microarray Analysis Identifies Commonalities in Neuronal Injury: Evidence for Oxidative Stress, Dysfunction of Calcium Signalling, and Inhibition of Autophagy-Lysosomal Pathway.Neurochemical research · 2016Review
- Article
- Induction of entosis by epithelial cadherin expression.Cell research · 2014Article
- Engulfing losers by winners in cancer: do cancer stem cells catch eat-me signals from noncancer stem cells?Future oncology (London, England) · 2014Article
- CCAAT-enhancer binding protein-β expression and elevation in Alzheimer's disease and microglial cell cultures.PloS one · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Descriptions of various processes that lead to cell-in-cell structures have been reported for decades. The exact molecular mechanism(s) of their formation and the physiological significance of cell-in-cell structures remain poorly understood. We had previously shown that an isoform of the CCAAT/enhancer-binding protein beta (C/EBPbeta) transcription factor, liver-enriched inhibitory protein (LIP), induces cell death in human breast cancer cells and stimulates autophagy. Here we describe a non-apoptotic cell death process where LIP mediates the engulfment of neighboring cells. We provide evidence of LIP-mediated engulfment via DNA profiling, fluorescent imaging and cell sorting studies, as well as ultrastructure analysis of LIP-expressing MDA-MB-468 breast cancer cells. Our work illustrates that expression of a specific transcription factor, LIP, can mediate cell engulfment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.