ArticlePloS one2012
Deep sequencing-based transcriptome analysis of chicken spleen in response to avian pathogenic Escherichia coli (APEC) infection.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Transcription profiles of chicken liver and spleen in response to infection with avian pathogenic Escherichia coli at different stages.Poultry science · 2026Article
- Spleen-based proteogenomics reveals thatVirulence · 2023Article
- Transcriptome responses of intestinal epithelial cells induced by membrane vesicles ofCurrent research in microbial sciences · 2023Article
- Effects of glucose oxidase on growth performance, immune function, and intestinal barrier of ducks infected with Escherichia coli O88.Poultry science · 2020Article
- Identification of Gene Modules and Hub Genes Involved in Mastitis Development Using a Systems Biology Approach.Frontiers in genetics · 2020Article
- Dynamic Interplay of Host and Pathogens in an Avian Whole-Blood Model.Frontiers in immunology · 2020Article
- RNA-seq profiles of chicken type II pneumocyte in response to Escherichia coli infection.PloS one · 2019Article
- Messenger RNA Sequencing and Pathway Analysis Provide Novel Insights Into the Susceptibility toFrontiers in genetics · 2018Article
- Characterization of Spleen Transcriptome and Immunity Against Avian Colibacillosis After Immunization With Recombinant AttenuatedFrontiers in veterinary science · 2018Article
- Gene Expression Profiling of Broiler Liver under Cold Stress by High-Throughput Sequencing Technology.The journal of poultry science · 2017Article
- Novel MicroRNA Involved in Host Response to Avian Pathogenic Escherichia coli Identified by Deep Sequencing and Integration Analysis.Infection and immunity · 2017Article
- A recombinant multi-antigen vaccine with broad protection potential against avian pathogenic Escherichia coli.PloS one · 2017Article
- Article
- The co-transcriptome of uropathogenic Escherichia coli-infected mouse macrophages reveals new insights into host-pathogen interactions.Cellular microbiology · 2015Article
- DNA methylome in spleen of avian pathogenic Escherichia coli-challenged broilers and integration with mRNA expression.Scientific reports · 2014Article
- Characterization of the rainbow trout spleen transcriptome and identification of immune-related genes.Frontiers in genetics · 2014Article
- Article
- Transcriptome analysis of the Portunus trituberculatus: de novo assembly, growth-related gene identification and marker discovery.PloS one · 2014Article
- Article
Corrections and comments
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5 authors.
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Abstract
Avian pathogenic Escherichia coli (APEC) leads to economic losses in poultry production and is also a threat to human health. The goal of this study was to characterize the chicken spleen transcriptome and to identify candidate genes for response and resistance to APEC infection using Solexa sequencing. We obtained 14422935, 14104324, and 14954692 Solexa read pairs for non-challenged (NC), challenged-mild pathology (MD), and challenged-severe pathology (SV), respectively. A total of 148197 contigs and 98461 unigenes were assembled, of which 134949 contigs and 91890 unigenes match the chicken genome. In total, 12272 annotated unigenes take part in biological processes (11664), cellular components (11927), and molecular functions (11963). Summing three specific contrasts, 13650 significantly differentially expressed unigenes were found in NC Vs. MD (6844), NC Vs. SV (7764), and MD Vs. SV (2320). Some unigenes (e.g. CD148, CD45 and LCK) were involved in crucial pathways, such as the T cell receptor (TCR) signaling pathway and microbial metabolism in diverse environments. This study facilitates understanding of the genetic architecture of the chicken spleen transcriptome, and has identified candidate genes for host response to APEC infection.
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