ArticleInternational journal of medical sciences2012
Symptomatic venous thromboembolism is a disease related to infection and immune dysfunction.
Article in International journal of medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Venous thromboembolism is linked to severity of disease in COVID-19 patients: A systematic literature review and exploratory meta-analysis.International journal of clinical practice · 2021Pooled it
- The Diagnostic Utility of Natural Killer Cell Subsets in Deep Vein Thrombosis.Vascular health and risk management · 2023Article
- Comprehensive bioinformatics analysis reveals the crosstalk genes and immune relationship between the systemic lupus erythematosus and venous thromboembolism.Frontiers in immunology · 2023Article
- Article
- Venous Thromboembolism in COVID-19.Thrombosis and haemostasis · 2020Review
- The role of bone marrow-derived cells in venous thromboembolism.The international journal of biochemistry & cell biology · 2020Review
- Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia.Journal of thrombosis and haemostasis : JTH · 2020Article
- Cytokines, Adhesion Molecules, and Matrix Metalloproteases as Predisposing, Diagnostic, and Prognostic Factors in Venous Thrombosis.Frontiers in medicine · 2018Review
- Differential co-expression analysis of venous thromboembolism based on gene expression profile data.Experimental and therapeutic medicine · 2016Article
- Characterization of immune cells and perforin mutations in familiar venous thromboembolism.International journal of clinical and experimental medicine · 2015Article
- The origin and onset of acute venous thrombus.International journal of clinical and experimental medicine · 2015Review
- Increased Expressions of Integrin Subunit β1, β2 and β3 in Patients with Acute Infection.International journal of medical sciences · 2015Article
- Activation of circulated immune cells and inflammatory immune adherence are involved in the whole process of acute venous thrombosis.International journal of clinical and experimental medicine · 2014Article
- Prothrombotic Milieu, Thrombotic Events and Prophylactic Anticoagulation in Hospitalized COVID-19 Positive Patients: A Review.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The characteristics of human genomics and cellular immune function between clinically symptomatic venous thromboembolism (VTE) and controls were systematically compared to explore the immunologic pathogenesis of VTE. Microarray assay showed the mRNA expressions of genes related to non-specific cellarer immune and cytokines were significantly down-regulated. Abnormal expressions of CD3+, CD4+, CD8+, NK marker CD16+56+, CD19 and aberrant CD4+/CD8+ ratio were detected in 54 among 56 patients. In PE patients, microarray assay revealed the imbalance in the expressions of genes related to the immune system. The expressions of genes related to non-specific immune cells and cytokines were markedly up-regulated and those associated with cellular immune were dramatically down-regulated. In VTE patients, cytological examination indicated the functions of NK cells were significantly compromised, and the antigen recognition and killing function of T cells markedly decreased. The consistence between genomic and cytological examination suggests the symptomatic VTE is closely associated with the infection and immune dysfunction.
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Registered trials
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