Evidence map›Paper›PMID 22859645›Full record

ArticleJournal of the American Medical Informatics Association : JAMIA2013

Large-scale evaluation of automated clinical note de-identification and its impact on information extraction.

Louise Deleger, Katalin Molnar, Guergana Savova, Fei Xia, Todd Lingren, Qi Li, Keith Marsolo, Anil Jegga, Megan Kaiser, Laura Stoutenborough and 1 more

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Journal of the American Medical Informatics Association : JAMIA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
22.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 88 citations in OpenAlex.

  1. Article
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  8. Improving domain adaptation in de-identification of electronic health records through self-training.Journal of the American Medical Informatics Association : JAMIA · 2021
    Article
  9. Review
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  15. Efficient Active Learning for Electronic Medical Record De-identification.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2019
    Article
  16. Article
  17. Article
  18. Phelan-McDermid syndrome data network: Integrating patient reported outcomes with clinical notes and curated genetic reports.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Louise DelegerDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.
Katalin Molnar
Guergana Savova
Fei Xia
Todd Lingren
Qi Li
Keith Marsolo
Anil Jegga
Megan Kaiser
Laura Stoutenborough
Imre Solti
Cincinnati Children's Hospital Medical Center · USBoston Children's Museum · USUniversity of Washington · US

Funding

Informatics for Integrating Biology/ the Bedside (RMI)U54LM008748 · NLM · BRIGHAM AND WOMEN'S HOSPITAL · PI KOHANE, ISAAC S. · 2004 to 2013
$39.0M
Increasing Clinical Trial Enrollment: A Semi-Automated Patient Centered ApproachR00LM010227 · NLM · CINCINNATI CHILDRENS HOSP MED CTR · PI SOLTI, IMRE · 2010 to 2012
$727k
Increasing Clinical Trial Enrollment: A Semi-Automated Patient Centered ApproachK99LM010227 · NLM · UNIVERSITY OF WASHINGTON · PI SOLTI, IMRE · 2009 to 2009
$84k
NLM NIH HHS 5R00LM010227-04NLM NIH HHS K99 LM010227NLM NIH HHS R00 LM010227NLM NIH HHS U54 LM008748
6 · The paper itself

Abstract

objective(1) To evaluate a state-of-the-art natural language processing (NLP)-based approach to automatically de-identify a large set of diverse clinical notes. (2) To measure the impact of de-identification on the performance of information extraction algorithms on the de-identified documents. MATERIAL AND

methodsA cross-sectional study that included 3503 stratified, randomly selected clinical notes (over 22 note types) from five million documents produced at one of the largest US pediatric hospitals. Sensitivity, precision, F value of two automated de-identification systems for removing all 18 HIPAA-defined protected health information elements were computed. Performance was assessed against a manually generated 'gold standard'. Statistical significance was tested. The automated de-identification performance was also compared with that of two humans on a 10% subsample of the gold standard. The effect of de-identification on the performance of subsequent medication extraction was measured.

resultsThe gold standard included 30 815 protected health information elements and more than one million tokens. The most accurate NLP method had 91.92% sensitivity (R) and 95.08% precision (P) overall. The performance of the system was indistinguishable from that of human annotators (annotators' performance was 92.15%(R)/93.95%(P) and 94.55%(R)/88.45%(P) overall while the best system obtained 92.91%(R)/95.73%(P) on same text). The impact of automated de-identification was minimal on the utility of the narrative notes for subsequent information extraction as measured by the sensitivity and precision of medication name extraction. DISCUSSION AND

conclusionNLP-based de-identification shows excellent performance that rivals the performance of human annotators. Furthermore, unlike manual de-identification, the automated approach scales up to millions of documents quickly and inexpensively.

Indexed as

ConfidentialityData MiningElectronic Health RecordsInformation DisseminationNatural Language ProcessingAlgorithmsCross-Sectional StudiesHospitals, PediatricHumansObserver VariationReproducibility of ResultsTechnology Assessment, BiomedicalUnited States

Identifiers

PMID22859645
PMCPMC3555323
OpenAlexW2164695063

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.