ArticleAmerican journal of physiology. Renal physiology2012
Genetic analysis of albuminuria in collaborative cross and multiple mouse intercross populations.
Article in American journal of physiology. Renal physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Indirect podocyte injury manifested in a partial podocytectomy mouse model.American journal of physiology. Renal physiology · 2021Article
- Genetic basis of voluntary water consumption in two divergently selected strains of inbred mice.Veterinary medicine and science · 2019Article
- High-Diversity Mouse Populations for Complex Traits.Trends in genetics : TIG · 2019Review
- Mapping novel genetic loci associated with female liver weight variations using Collaborative Cross mice.Animal models and experimental medicine · 2018Article
- The Collaborative Cross mouse model for dissecting genetic susceptibility to infectious diseases.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Genetic, maternal, and heterosis effects on voluntary water consumption in mice.Journal of animal science · 2018Article
- Using the Collaborative Cross to Study the Role of Genetic Diversity in Cancer-Related Phenotypes.Cold Spring Harbor protocols · 2016Article
- Dissecting the Effect of Genetic Variation on the Hepatic Expression of Drug Disposition Genes across the Collaborative Cross Mouse Strains.Frontiers in genetics · 2016Article
- Contrasting genetic architectures in different mouse reference populations used for studying complex traits.Genome research · 2015Review
- Splicing landscape of the eight collaborative cross founder strains.BMC genomics · 2015Article
- Genetic determinants of atherosclerosis, obesity, and energy balance in consomic mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Article
- Fine-mapping QTLs in advanced intercross lines and other outbred populations.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Review
- Out of the bottleneck: the Diversity Outcross and Collaborative Cross mouse populations in behavioral genetics research.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Review
- QTL mapping in outbred populations: successes and challenges.Physiological genomics · 2014Review
- Mouse phenome database.Nucleic acids research · 2014Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
Albuminuria is an important marker of nephropathy that increases the risk of progressive renal and chronic cardiovascular diseases. The genetic basis of kidney disease is well-established in humans and rodent models, but the causal genes remain to be identified. We applied several genetic strategies to map and refine genetic loci affecting albuminuria in mice and translated the findings to human kidney disease. First, we measured albuminuria in mice from 33 inbred strains, used the data for haplotype association mapping (HAM), and detected 10 genomic regions associated with albuminuria. Second, we performed eight F(2) intercrosses between genetically diverse strains to identify six loci underlying albuminuria, each of which was concordant to kidney disease loci in humans. Third, we used the Oak Ridge National Laboratory incipient Collaborative Cross subpopulation to detect an additional novel quantitative trait loci (QTL) underlying albuminuria. We also performed a ninth intercross, between genetically similar strains, that substantially narrowed an albuminuria QTL on Chromosome 17 to a region containing four known genes. Finally, we measured renal gene expression in inbred mice to detect pathways highly correlated with albuminuria. Expression analysis also identified Glcci1, a gene known to affect podocyte structure and function in zebrafish, as a strong candidate gene for the albuminuria QTL on Chromosome 6. Overall, these findings greatly enhance our understanding of the genetic basis of albuminuria in mice and may guide future studies into the genetic basis of kidney disease in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.